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1-Piperazinebutanenitrile, 4-(2-methoxyphenyl)- is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 25024-99-1 Structure
  • Basic information

    1. Product Name: 1-Piperazinebutanenitrile, 4-(2-methoxyphenyl)-
    2. Synonyms:
    3. CAS NO:25024-99-1
    4. Molecular Formula: C15H21N3O
    5. Molecular Weight: 259.351
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 25024-99-1.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1-Piperazinebutanenitrile, 4-(2-methoxyphenyl)-(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1-Piperazinebutanenitrile, 4-(2-methoxyphenyl)-(25024-99-1)
    11. EPA Substance Registry System: 1-Piperazinebutanenitrile, 4-(2-methoxyphenyl)-(25024-99-1)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 25024-99-1(Hazardous Substances Data)

25024-99-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 25024-99-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,5,0,2 and 4 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 25024-99:
(7*2)+(6*5)+(5*0)+(4*2)+(3*4)+(2*9)+(1*9)=91
91 % 10 = 1
So 25024-99-1 is a valid CAS Registry Number.

25024-99-1Relevant articles and documents

Synthesis, in silico, and in vitro studies of novel dopamine D2 and D3 receptor ligands

Elek, Milica,Djokovic, Nemanja,Frank, Annika,Oljacic, Slavica,Zivkovic, Aleksandra,Nikolic, Katarina,Stark, Holger

, (2021/02/26)

Dopamine is an important neurotransmitter in the human brain and its altered concentrations can lead to various neurological diseases. We studied the binding of novel compounds at the dopamine D2 (D2R) and D3 (D3/sub

Compound with dopamine D3 receptor adjusting activity, and applications thereof

-

Paragraph 0155; 0164; 0166, (2019/03/22)

The invention relates to a compound with dopamine D3 receptor adjusting activity, and applications thereof, and more specifically discloses dopamine receptor D3R as a novel target of post-traumatic stress disorder (PTSD) in prevention, treatment/or auxiliary treatment of PTSD, and screening of anti-PTSD medicines, and relates to applications of a compound with dopamine receptor D3R adjusting activity in preparation of medicines used for preventing, treatment and/or auxiliary treatment of PTSD.

Fast and efficient 18F-labeling by [18F]fluorophenylazocarboxylic esters

Fehler, Stefanie K.,Maschauer, Simone,Hcfling, Sarah B.,Bartuschat, Amelie L.,Tschammer, Nuska,Hubner, Harald,Gmeiner, Peter,Prante, Olaf,Heinrich, Markus R.

supporting information, p. 370 - 375 (2014/04/03)

Introduction of [18F]fluoride ion into the aromatic core of phenylazocarboxylic esters was achieved in only 30 seconds, with radiochemical yields of up to 95% (85(±10) %). For labeling purposes, the resulting 18F-substituted azoester can be further converted in radical-arylation reactions to give biaryls, or in substitutions at its carbonyl unit to produce azocarboxamides.

Synthesis and pharmacological evaluation of [(4-Arylpiperazin-1-yl)-alkyl]- carbamic acid ethyl ester derivatives as potential anxiolytic agents

Khatri, Manisha,Rai, Santosh K.,Ranbhor, Ranjit,Kishore, Krishna,Tiwari, Manisha

experimental part, p. 1143 - 1152 (2012/11/07)

On the basis of our earlier studies, a series of N-{4-[4-(aryl) piperazin-1-yl]-phenyl}-amine derivatives containing terminal carbamoyl fragment with alkyl spacer of different lengths (15-20) were synthesized as ligands, for 5-hydroxytryptamine-1A (5-HT1A

Preparation, characterization, and screening of a high affinity organometallic probe for α-adrenergic receptors

Louie, Anika S.,Vasdev, Neil,Valliant, John F.

experimental part, p. 3360 - 3367 (2011/06/22)

Figure Presented. An organometallic rhenium complex having high and selective affinity for α-adrenergic receptors is reported. A series of methoxyphenylpiperazinecarborane ligands complexed to the [Re(CO) 3]+ core were prepared and t

Synthesis, biological evaluation and radiolabelling by 18F- fluoroarylation of a dopamine D3-selective ligand as prospective imaging probe for PET

H?fling,Maschauer,Hübner,Gmeiner,Wester,Prante,Heinrich

supporting information; experimental part, p. 6933 - 6937 (2011/03/17)

Radical 18F-fluoroarylation with fluorine-18-labelled arenediazonium chlorides has been successfully applied to the radiochemical synthesis of the dopamine D3-selective ligand SH 317 ([ 18F]8). SH 317 has been evaluated as

Bioisosteric replacement leading to biologically active [2.2]Paracyclophanes with altered binding profiles for aminergic g-protein-coupled receptors

Skultety, Marika,Hübner, Harald,L?ber, Stefan,Gmeiner, Peter

experimental part, p. 7219 - 7228 (2010/12/25)

Exploring the chemical diversity space of GPCR ligands, we recently discovered [2.2]paracyclophanes as valuable atypical bioisosteres for secondary affinity and selectivity generating moieties. To find out if such an exchange also works for structural moieties that simulate the endogenous neurotransmitter, π1 or π2 or both systems π1 and π2 of three representative privileged structures of types 1, 2, and 3 were replaced by a [2.2]paracyclophane unit. Contributions of the respective functionalities to the binding affinities of a panel of relevant monoaminergic GPCRs were systematically examined. The study led to the paracyclophanylpiperazine 3a displaying excellent D3 affinity (Ki = 1.6 nM) and a strongly attenuated binding to D4, 5-HT1 and α1. Whereas functional experiments showed neutral D3 antagonist properties, mutagenesis studies indicated a binding mode that is similar to its lead compounds of type 3.

Synthesis and evaluation of amides surrogates of dopamine D3 receptor ligands

Jean, Micka?l,Renault, Jacques,Levoin, Nicolas,Danvy, Denis,Calmels, Thierry,Berrebi-Bertrand, Isabelle,Robert, Philippe,Schwartz,Lecomte,Uriac, Philippe,Capet, Marc

scheme or table, p. 5376 - 5379 (2010/12/24)

Isosteric replacement of the amide function and modulation of the arylpiperazine moiety of known dopamine D3 receptor ligands led to potent and selective compounds. Enhanced bioavailability and preferential brain distribution make compound 6c a good candi

Solventless microwave assisted protocol for synthesis of arylalkylpiperazines using Cs-base

Giuglio-Tonolo, Alain Gamal,Terme, Thierry,Vanelle, Patrice

experimental part, p. 160 - 162 (2010/04/22)

A series of some arylalkylpiperazines was prepared in good yields under microwave irradiation in dry media conditions using CsOH with high chemo- and regioselectivity.

3,4-dihydro-2-naphthamide derivatives as selective dopamine D3 ligands

-

Page/Page column 10, (2008/06/13)

The invention relates to 3,4-dihydro-2-naphthamide derivatives of formula (I), pharmaceutical compositions containing them and their therapeutic applications as partial agonists or antagonists of the dopamine D3 receptor for the treatment of neuropsychological disorders.

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