250284-66-3Relevant academic research and scientific papers
Effects of a verbenachalcone derivative on neurite outgrowth, inhibition of caspase induction and gene expression
Yeh, Li-An,Padmanaban, Deppa,Ho, Pei,Xing, Xeuchao,Rowley, Patricia,Morse, Lee Jae,Jensen, Roderick V.,Cuny, Gregory D.
, p. 1193 - 1196 (2005)
A verbenachalcone derivative was synthesized and shown to protect N2a cells from caspase induction caused by serum starvation and to enhance the effect of NGF on neurite outgrowth in PC12 cells. As an initial investigation of the compound's mechanism(s) o
Transition Metal Free C-N Bond Forming Dearomatizations and Aryl C-H Aminations by in Situ Release of a Hydroxylamine-Based Aminating Agent
Farndon, Joshua J.,Ma, Xiaofeng,Bower, John F.
supporting information, p. 14005 - 14008 (2017/10/17)
We outline a simple protocol that accesses directly unprotected secondary amines by intramolecular C-N bond forming dearomatization or aryl C-H amination. The method is dependent on the generation of a potent electrophilic aminating agent released by in situ deprotection of O-Ts activated N-Boc hydroxylamines.
A Simple and Broadly Applicable C?N Bond Forming Dearomatization Protocol Enabled by Bifunctional Amino Reagents
Ma, Xiaofeng,Farndon, Joshua J.,Young, Tom A.,Fey, Natalie,Bower, John F.
supporting information, p. 14531 - 14535 (2017/10/18)
A C?N bond forming dearomatization protocol with broad scope is outlined. Specifically, bifunctional amino reagents are used for sequential nucleophilic and electrophilic C?N bond formations, with the latter effecting the key dearomatization step. Using t
Liebeskind-srogl cross coupling mediated synthesis of verbenachalcone
Dandepally, Srinivasa Reddy,Williams, Alfred L.
scheme or table, p. 5753 - 5756 (2010/11/05)
A flexible and scalable total synthesis of verbenachalcone is achieved in eight linear steps from cheap commercially available starting material, 3-(4-hydroxyphenyl)propanoic acid.
Antagonists of the calcium receptor. 2. Amino alcohol-based parathyroid hormone secretagogues
Marquis, Robert W.,Lago, Amparo M.,Callahan, James F.,Rahman, Attiq,Dong, Xiaoyang,Stroup, George B.,Hoffman, Sandra,Gowen, Maxine,DelMar, Eric G.,Van Wagenen, Bradford C.,Logan, Sarah,Shimizu, Scott,Fox, John,Nemeth, Edward F.,Roethke, Theresa,Smith, Brian R.,Ward, Keith W.,Bhatnagar, Pradip
experimental part, p. 6599 - 6605 (2010/04/03)
When administered as a single agent to rats, the previously reported calcium receptor antagonist 3 elicited a sustained elevation of plasma PTH resulting in no increase in overall bone mineral density. The lack of a bone building effect for analogue 3 was
Utilization of a copper-catalyzed diaryl ether synthesis for the preparation of verbenachalcone
Xing, Xuechao,Padmanaban, Deepa,Yeh, Li-An,Cuny, Gregory D
, p. 7903 - 7910 (2007/10/03)
2-Hydroxy-2′-methoxydiphenyl ethers were efficiently assembled utilizing a catalytic copper mediated coupling of 2-benzyloxybromobenzene derivatives and 2-methoxyphenol derivatives in the presence of cesium carbonate in pyridine followed by debenzylation.
