250371-88-1

Basic information

• Product Name: 1-(4-Boc-piperidinyl-1-oxy)-2-fluoro-4-nitrobenzene
• Synonyms: 1-(4-Boc-piperidinyl-1-oxy)-2-fluoro-4-nitrobenzene;1-Boc-4-(2-fluoro-4-nitrophenoxy)piperidine;tert-Butyl 4-(2-fluoro-4-nitrophenoxy)piperidine-1-carboxylate
• CAS NO: 250371-88-1
• Molecular Formula: C₁₆H₂₁FN₂O₅
• Molecular Weight: 341.3546832
• Mol File: 250371-88-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 461.0±45.0 °C(Predicted)
• Appearance: /
• Density: 1.259±0.06 g/cm3(Predicted)
• Storage Temp.: Room temperature.
• PKA: -2.77±0.40(Predicted)
• CAS DataBase Reference: 1-(4-Boc-piperidinyl-1-oxy)-2-fluoro-4-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Boc-piperidinyl-1-oxy)-2-fluoro-4-nitrobenzene(250371-88-1)
• EPA Substance Registry System: 1-(4-Boc-piperidinyl-1-oxy)-2-fluoro-4-nitrobenzene(250371-88-1)

Safety Data

• Hazardous Substances Data: 250371-88-1(Hazardous Substances Data)

Usage

General Description

1-(4-Boc-piperidinyl-1-oxy)-2-fluoro-4-nitrobenzene is a chemical compound with a molecular formula C17H20FN2O5. It is a fluorinated organic compound with a piperidinyl-1-oxy and nitro substituent. The compound is commonly used in chemical research and drug development due to its unique structure and properties. It is known for its potential use in medicinal chemistry and pharmacology, as well as in the development of new pharmaceutical agents. The compound is also used as a building block in the synthesis of various biologically active molecules and pharmaceutical compounds. Furthermore, it is known to have potential applications in the field of organic and medicinal chemistry.

Upstream product

• 369-34-6 3,4-difluoronitrobenzene 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 403-19-0 2-fluoro-4-nitrophenol 

Downstream Products

• 250372-00-0 4-[1-(t-butoxycarbonyl)piperidin-4-yloxy]-3-fluoroaniline 
• 405887-42-5 C₂₀H₃₁FN₂O₅Si 
• 405887-43-6 C₂₀H₃₁FN₂O₅Si 
• 1126430-36-1 4-[(2-fluoro-4-nitrophenyl)oxy]piperidine trifluoroacetate 
• 346664-40-2 tert-butyl 4-(4-{(5S)-5-[(acetyl amino)methyl]-2-oxo-1,3-oxazolidin-3-yl}-2-fluorophenoxy)piperidine-1-carboxylate 
• 250372-89-5 tert-butyl 4-[2-fluoro-4-((5R)-5-{[(methylsulfonyl)oxy]methyl}-2-oxo-1,3-oxazolidin-3-yl)phenoxy]piperidine-1-carboxylate 
• 250373-24-1 4-[4-(5-azidomethyl-2-oxo-oxazolidin-3-yl)-2-fluoro-phenoxy]-piperidine-1-carboxylic acid tert-butyl ester 
• 250372-19-1 2-fluoro-1-{N-(t-butoxycarbonyl)piperidinyl-4-oxy}-4-(benzyloxycarbonylamino)benzene 
• 250372-38-4 (R)-[3-[3-fluoro-4-{N-(t-butoxycarbonyl)piperidinyl-4-oxy}phenyl]-2-oxo-5-oxazolidinyl]-methanol 

Relevant articles and documents

THIAZOLE AND OXAZOLE KINASE INHIBITORS

The present invention provides thiazole and oxazole compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.

Cinnamylindoline derivatives: Synthesis and factor Xa (FXa) inhibitory activities

A series of cinnamylindoline derivatives were synthesized, and their factor Xa (FXa) inhibitory activities and selectivity over trypsin were evaluated. Among them, some novel derivatives showed potent FXa inhibitory activities and good selectivity over trypsin. Especially, (E)-2-{5-[1-(acetimidoyl)piperidin-4- yloxy]-2-[2-(5-amidino-2-hydroxyphenyl)ethen-1-yl]indolin-1-ylsulfonyl}acetic acid (22f) having 2-hydroxycinnamyl moiety exhibited the most potent FXa inhibitory activity in vitro. Furthermore, 22f also exhibited potent anticoagulant activities in vitro.