250688-98-3

Upstream product

• 773-64-8 2-mesitylenesulphonyl chloride 
• 372188-11-9 2-amino-3-{[5-(2-methoxycarbonyl-ethyl)-thiophene-2-carbonyl]-amino}-propionic acid tert-butyl ester 
• 7311-63-9 5-bromothiophene-2-carboxylic acid 
• 250688-80-3 5-(2-methoxycarbonylethyl)thiophene-2-carboxylic acid 
• 259226-88-5 5-(2-methoxycarbonyl-vinyl)-thiophene-2-carboxylic acid 
• 250688-81-4 2-benzyloxycarbonylamino-3-{[5-(2-methoxycarbonyl-ethyl)-thiophene-2-carbonyl]-amino}-propionic acid tert-butyl ester 
• 7087-68-5 N-ethyl-N,N-diisopropylamine 

Downstream Products

• 250688-99-4 (2S)-3-((5-(2-(1,4,5,6-Tetrahydropyrimidin-2-ylcarbamoyl)-ethyl)-thiophene-2-carbonyl)-amino)-2-(2,4,6-trimethylphenyl-sulfonylamino)-propionic Acid tert-Butyl Ester 

Relevant academic research and scientific papers

Thienyl substituted acylguanidines as inhibitors of bone resorption and vitronectin receptor antagonists

Compounds of the formula and salts thereof wherein the substituents are defined as in accordance with the specification useful for the treatment of tumor growth, osteoporosis, inflammation and cardiovascular disorders.

αvβ3 antagonists based on a central thiophene scaffold

A series of novel, highly potent αvβ3 antagonists based on a thiophene scaffold and containing an acylguanidine as an Arg-mimetic is described. A number of structural features, such as cyclic versus open guanidine and a variety of li