251099-41-9

Upstream product

• 251099-37-3 (3R,4R,5R,6S)-6,7-Bis-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-3,5-dimethyl-heptan-2-one 
• 1125-88-8 benzaldehyde dimethyl acetal 
• 251099-39-5 (2R,3S,4S,5R,6S)-6,7-(di(tert-butyldimethylsilyloxy))-3,5-dimethylheptane-2,4-diol 
• 251099-31-7 (E)-(5R,6S)-6,7-Dihydroxy-5-methyl-hept-3-enoic acid methyl ester 
• 184528-65-2 (E)-(5S,6S,7R,8S)-8,9-Bis-(tert-butyl-dimethyl-silanyloxy)-6-hydroxy-4,5,7-trimethyl-non-3-enoic acid methyl ester 
• 69739-34-0 t-butyldimethylsiyl triflate 
• 251099-32-8 methyl (5R,6S)-(E)-6,7-(di(tert-butyldimethylsilyloxy))-5-methyl-3-heptenoate 
• 184528-64-1 (2S,3S)-3,4-(di(tert-butyldimethylsilyloxy))-2-methyl-butanal 

Downstream Products

• 251099-43-1 (2S,3R,4S,5S,6R)-2-(tert-butyldimethylsilyloxy)-4,6-((R)-benzylidenedioxy)-3,5-dimethylheptanol 
• 251099-45-3 (2S,3R,4S,5S,6R)-2-(tert-butyldimethylsilyloxy)-4,6-((R)-benzylidenedioxy)-3,5-dimethylheptanal 
• 251099-47-5 (3S,4R,5S,6S,7R)-3-(tert-butyldimethylsilyloxy)-5,7-((R)-benzylidenedioxy)-4,6-dimethyloctan-2-one 
• 251099-49-7 (3S,4R,5S,6S,7R)-3-(tert-butyldimethylsilyloxy)-5,7-((R)-benzylidenedioxy)-4,6-dimethyl-1-octene-2-yl-trifluoromethanesulfonate 
• 251099-51-1 (2S,3R,4R,5S,6S,9S,10R,11S,12S,13R)-9-(tert-butyldimethylsiloxy)-11,13-((R)-benzylidenedioxy)-3,5-(isopropylidenedioxy)-8-methylene-2,4,6,10,12-pentamethyltetradecan-1-ol 
• 251099-50-0 (2R,3S,4S,5R,6S,9S,10S,11R,12R,13S)-6-(tert-butyldimethylsiloxy)-14-((tert-butyldiphenylsiloxy))-2,4-((R)-benzylidenedioxy)-10,12-(isopropylidenedioxy)-7-methylene-3,5,9,11,13-pentamethyltetradecane 
• 476622-79-4 (2R,3S,4R,5S,6S,9S,10R,11S,12S,13R)-9-(tert-butyldimethylsiloxy)-11-benzyloxy-13-hydroxy-3,5-(isopropylidenedioxy)-8-methylene-2,4,6,10,12-pentamethyltetradecan-1-al 
• 476622-81-8 (2R,3S,4R,5S,6S,9S,10R,11S,12R,13R)-9-(tert-butyldimethylsiloxy)-11-benzyloxy-3,5-(isopropylidenedioxy)-8-methylene-2,4,6,10,12,13-hexamethyltetradecanolide 
• 476622-78-3 (2S,3R,4R,5S,6S,9S,10R,11S,12S,13R)-9-(tert-butyldimethylsiloxy)-11-benzyloxy-3,5-(isopropylidenedioxy)-8-methylene-2,4,6,10,12-pentamethyltetradecan-1,13-diol 
• 476622-80-7 (2R,3S,4R,5S,6S,9S,10R,11S,12S,13R)-9-(tert-butyldimethylsiloxy)-11-benzyloxy-13-hydroxy-3,5-(isopropylidenedioxy)-8-methylene-2,4,6,10,12-pentamethyltetradecanoic acid 
• 476622-77-2 (2R,3S,4S,5R,6S,9S,10S,11R,12R,13S)-6-(tert-butyldimethylsiloxy)-14-((tert-butyldiphenylsiloxy))-2,4-((R)-benzylidenedioxy)-10,12-(isopropylidenedioxy)-3,5,9,11,13-pentamethyltetradecan-7-on 
• 476622-76-1 (2R,3S,6S)-3-(tert-Butyl-dimethyl-silanyloxy)-6-{(4S,5R,6R)-6-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-2-((2R,4S,5S,6R)-5,6-dimethyl-2-phenyl-[1,3]dioxan-4-yl)-heptan-4-ol 

Relevant academic research and scientific papers

Asymmetric crotylation reactions in synthesis of polypropionate-derived macrolides: Application to total synthesis of oleandolide

Complete details of a convergent asymmetric synthesis of oleandolide (1), the aglycon of the macrolide antibiotic oleandomycin, is described. The synthesis has been achieved through the assembly and coupling of the left- and right-hand subunits 12 and 38,