476622-77-2

Upstream product

• 251099-23-7 methyl-(5S,6S,7R,8R,9S)-(E)-10-(tert-butyldiphenylsilyloxy)-6,8-(isopropylidenedioxy)-5,7,9-trimethyl-3-decenoate 
• 251099-21-5 methyl-(5S,6S,7R,8R,9S)-(E)-10-(tert-butyldiphenylsilyloxy)-6,8-dihydroxy-5,7,9-trimethyl-3-decenoate 
• 251099-27-1 (2R,3R,4S,5R,6S)-1-iodo-7-(tert-butyldiphenylsilyloxy)-3,5-(isopropylidenedioxy)-2,4,6-trimethyl-heptane 
• 251099-41-9 (2S,3R,4S,5S,6R)-1,2-(di(tert-butyldimethylsilyloxy))-4,6-((R)-benzylidenedioxy)-3,5-dimethylheptane 
• 251099-25-9 (2S,3S,4R,5R,6S)-7-(tert-butyldiphenylsilyloxy)-3,5-(isopropylidenedioxy)-2,4,6-trimethyl-heptanol 
• 251099-39-5 (2R,3S,4S,5R,6S)-6,7-(di(tert-butyldimethylsilyloxy))-3,5-dimethylheptane-2,4-diol 
• 251099-32-8 methyl (5R,6S)-(E)-6,7-(di(tert-butyldimethylsilyloxy))-5-methyl-3-heptenoate 
• 251099-43-1 (2S,3R,4S,5S,6R)-2-(tert-butyldimethylsilyloxy)-4,6-((R)-benzylidenedioxy)-3,5-dimethylheptanol 
• 251099-45-3 (2S,3R,4S,5S,6R)-2-(tert-butyldimethylsilyloxy)-4,6-((R)-benzylidenedioxy)-3,5-dimethylheptanal 
• 851889-69-5 (E)-(5S,6S,7R,8R,9S)-6,8,10-Trihydroxy-5,7,9-trimethyl-dec-3-enoic acid methyl ester 
• 184528-55-0 (3E,5R,6S,7S)-6,8-O-[bis-(1,1-dimethylethyl)silylene]-5,7-dimethylhex-3-enoic acid methyl ester 
• 184528-54-9 (3E,5R,6S,7S)-6,8-dihydroxy-5,7-dimethyloct-3-enoic acid methyl ester 
• 184758-35-8 (3E,5S,6S,7R,8R,9S)-(E)-8,10-O-[bis-(1,1-dimethylethyl)silylene]-6-hydroxy-5,7,9-trimethyldec-3-enoic acid methyl ester 
• 184528-56-1 (2S,3R,4S)-3,5-O-[bis-(1,1-dimethylethyl)silylene]-2,4-dimethylpropionaldehyde 

Downstream Products

• 476622-80-7 (2R,3S,4R,5S,6S,9S,10R,11S,12S,13R)-9-(tert-butyldimethylsiloxy)-11-benzyloxy-13-hydroxy-3,5-(isopropylidenedioxy)-8-methylene-2,4,6,10,12-pentamethyltetradecanoic acid 
• 476622-78-3 (2S,3R,4R,5S,6S,9S,10R,11S,12S,13R)-9-(tert-butyldimethylsiloxy)-11-benzyloxy-3,5-(isopropylidenedioxy)-8-methylene-2,4,6,10,12-pentamethyltetradecan-1,13-diol 
• 476622-81-8 (2R,3S,4R,5S,6S,9S,10R,11S,12R,13R)-9-(tert-butyldimethylsiloxy)-11-benzyloxy-3,5-(isopropylidenedioxy)-8-methylene-2,4,6,10,12,13-hexamethyltetradecanolide 
• 476622-79-4 (2R,3S,4R,5S,6S,9S,10R,11S,12S,13R)-9-(tert-butyldimethylsiloxy)-11-benzyloxy-13-hydroxy-3,5-(isopropylidenedioxy)-8-methylene-2,4,6,10,12-pentamethyltetradecan-1-al 
• 251099-51-1 (2S,3R,4R,5S,6S,9S,10R,11S,12S,13R)-9-(tert-butyldimethylsiloxy)-11,13-((R)-benzylidenedioxy)-3,5-(isopropylidenedioxy)-8-methylene-2,4,6,10,12-pentamethyltetradecan-1-ol 
• 251099-50-0 (2R,3S,4S,5R,6S,9S,10S,11R,12R,13S)-6-(tert-butyldimethylsiloxy)-14-((tert-butyldiphenylsiloxy))-2,4-((R)-benzylidenedioxy)-10,12-(isopropylidenedioxy)-7-methylene-3,5,9,11,13-pentamethyltetradecane 

Relevant academic research and scientific papers

Asymmetric crotylation reactions in synthesis of polypropionate-derived macrolides: Application to total synthesis of oleandolide

Complete details of a convergent asymmetric synthesis of oleandolide (1), the aglycon of the macrolide antibiotic oleandomycin, is described. The synthesis has been achieved through the assembly and coupling of the left- and right-hand subunits 12 and 38,