251111-15-6

Basic information

• Product Name: 3-(3,4,5-Trimethoxyphenyl)-2(E)-propenoic acid (3R,4S,5S,6R)-4-[2(R)-methyl-3(R)-(3-methyl-2-butenyl)oxiran-2-yl]-5-methoxy-1-oxaspiro[2.5]oct-6-yl ester
• Synonyms: CKD-731; 6-O-[3-(3,4,5-Trimethoxyphenyl)-2(E)-propenoyl]fumagillol
• CAS NO: 251111-15-6
• Molecular Formula: C₂₈H₃₈O₈
• Molecular Weight: 502.61026
• Mol File: 251111-15-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-(3,4,5-Trimethoxyphenyl)-2(E)-propenoic acid (3R,4S,5S,6R)-4-[2(R)-methyl-3(R)-(3-methyl-2-butenyl)oxiran-2-yl]-5-methoxy-1-oxaspiro[2.5]oct-6-yl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3,4,5-Trimethoxyphenyl)-2(E)-propenoic acid (3R,4S,5S,6R)-4-[2(R)-methyl-3(R)-(3-methyl-2-butenyl)oxiran-2-yl]-5-methoxy-1-oxaspiro[2.5]oct-6-yl ester(251111-15-6)
• EPA Substance Registry System: 3-(3,4,5-Trimethoxyphenyl)-2(E)-propenoic acid (3R,4S,5S,6R)-4-[2(R)-methyl-3(R)-(3-methyl-2-butenyl)oxiran-2-yl]-5-methoxy-1-oxaspiro[2.5]oct-6-yl ester(251111-15-6)

Safety Data

• Hazardous Substances Data: 251111-15-6(Hazardous Substances Data)

Upstream product

• 20329-98-0 (E)-3,4,5-trimethoxy-cinnamic acid 
• 35903-52-7 fumagillol 
• 10263-19-1 (E)-3-(3,4,5-trimethoxyphenyl)acryloyl chloride 

Relevant articles and documents

Design, synthesis and evaluation of a series of novel fumagillin analogues

A series of fumagillin analogues targeted at understanding tolerability of MetAP2 toward substitution at C4 and C6 were synthesized. Initially, the C6 side chain was maintained as cinnamoyl ester and C4 was modified. It was concluded that replacing the na