251111-15-6Relevant academic research and scientific papers
Design, synthesis and evaluation of a series of novel fumagillin analogues
Fardis, Maria,Pyun, Hyung-Jung,Tario, James,Jin, Haolun,Kim, Choung U.,Ruckman, Judy,Lin, Yun,Green, Louis,Hicke, Brian
, p. 5051 - 5058 (2007/10/03)
A series of fumagillin analogues targeted at understanding tolerability of MetAP2 toward substitution at C4 and C6 were synthesized. Initially, the C6 side chain was maintained as cinnamoyl ester and C4 was modified. It was concluded that replacing the na
Design and synthesis of highly potent fumagillin analogues from homology modeling for a human MetAP-2
Han, Cheol Kyu,Ahn, Soon Kil,Choi, Nam Song,Hong, Ryung Kee,Moon, Seung Kee,Chun, Hyoung Sik,Lee, Sang Joon,Kim, Jung Woo,Hong, Chung Il,Kim, Deukjoon,Yoon, Jeong Hyeok,No, Kyoung Tai
, p. 39 - 43 (2007/10/03)
New fumagillin analogues were designed through structure-based molecular modeling with a human methionine aminopeptidase-2. Among the fumagillin analogues, cinnamic acid ester derivative CKD-731 showed 1000-fold more potent proliferation inhibitory activi
