25112-82-7

Upstream product

• 126-39-6 2-ethyl-2-methyl-1,3-dioxolane 
• 6838-66-0 1,2-bis((trimethylsilyl)oxy)cyclopent-1-ene 
• 1193-55-1 2-methylcyclohexane-1,3-dione 
• 85098-51-7 S-ethylthioxanium fluoborate 
• 696-98-0 S-ethylthiolanium fluoborate 
• 124015-87-8 2-methyl-1,3-cyclohexanedione-dimethylhydrazone 
• 69948-55-6 3-(2,2-dimethylhydrazino)cyclohex-2-en-1-one 
• 75-03-6 ethyl iodide 

Downstream Products

• 186349-16-6 4-Bromo-2-ethyl-2-methyl-cyclohexane-1,3-dione 
• 1215287-85-6 trifluoro-methanesulfonic acid 6-ethyl-6-methyl-5-oxo-cyclohex-1-enyl ester 
• 119614-90-3 (2S,3S)-2-ethyl-2-methyl-3-(3',5'-dinitro)benzoyloxycyclohexanone 
• 116927-02-7 (2S,3S)-2-Ethyl-3-hydroxy-2-methyl-cyclohexanone 
• 119678-45-4 (2R,3S)-2-Ethyl-3-hydroxy-2-methyl-cyclohexanone 

Relevant academic research and scientific papers

Enantioselective desymmetrizing palladium catalyzed carbonylation reactions: The catalytic asymmetric synthesis of quaternary carbon center containing 1,3-dienes

A desymmetrization protocol has been used to develop a palladium catalyzed enantioselective carbonylation process. Achiral cyclic bis-alkenyltriflates are converted to their corresponding monoester derivatives with selectivities of up to 96% ee. The Royal

Regioselective alkylations of cyclic 1,3-diketones via metalated dimethylhydrazones

Cyclic 1,3- diketones 1 are transformed into their 2,2-dimethylhydrazones 2, which can be alkylated regioselectively at different positions after mono-, di-, tri-, and tetrametalation. Monometalated C-2 unsubstituted hydrazones afford C-2 and N- alkylation, monometalated C-2 substituted hydrazones afford only C-2 alkylation.The regioselectivity of the alkylation of the polymetalated hydrazones follows Hauser's rule according to the sequence: NH- > C-4 Ha > C-5 > C-4 Hb. Hydrolysis of the product hydrazones 3-5 afforded mono- and polyalkylated 1,3- diketones 7 in good yields.

Resonance energy of diradicals - 1,8-naphthoquinodimethane

From the racemization of 19c and the temperature and NO dependence of the trapping rate of 20b between 218 and 288°C the energy profile for the equilibrium 19b ? 20b is derived. The singlet-triplet splitting of the diradical is 2.5 kcal · mol-1 with the triplet being the ground state. By comparison of the experimental reaction enthalpy with the analogous value for 25, 26 or a hypothetical model reaction with non-interacting radicals it is shown that the stabilizing interaction of the radicals in the singlet state of 20b is negligible making the stabilization of the triplet equivalent to the singlet-triplet splitting. By using literature data it is shown by an analogous analysis that the interaction of the radicals in the bisallyl diradical 28 and in the triplet state of the trimethylenmethane derivative 29 is also negligible whereas in the singlet state of 29 the interaction is strongly destabilizing. VCH Verlagsgesellschaft mbH, 1996.

A RE-EXAMINATION OF THE ACID-CATALYSED REACTION OF KETALS WITH 1,2-BIS(TRIMETHYLSILOXY)CYCLOPENTENE

Ketals react with 1,2-bis(trimethylsiloxy)cyclopentene in the presence of a large excess of boron trifluoride etherate to provide 2,2-disubstituted 1,3-cyclohexanediones in very good yields.

SYNTHESIS OF ENANTIOMERICALLY PURE (10R, 11S)-(+)-JUVENILE HORMONES I AND II

Enantiomerically pure (+)-juvenile hormone I18JH=JH I> and (+)-juvenile hormone II 17 JH=JH II> were synthesized employing the enantioselective reduction of 2-ethyl-2-methyl-1,3-cyclohexanedione by a yeast (Pichia terricola KI0117) as the key step.