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11βH,13-Dihydroparthenolide is a sesquiterpene lactone derived from the plant Parthenium hysterophorus, which is commonly known as Santa Maria or Carrizo. This chemical compound exhibits anti-inflammatory and immunosuppressive properties, making it a potential candidate for the treatment of various inflammatory and autoimmune diseases. It works by inhibiting the production of pro-inflammatory cytokines and suppressing the activation of immune cells, such as T-cells and macrophages. The compound's structure is characterized by a tricyclic ring system with a lactone group, and it is a reduced form of parthenolide, which is the primary active component of feverfew, a plant used for its medicinal properties. Research on 11βH,13-Dihydroparthenolide is ongoing to further understand its therapeutic potential and optimize its use in medical applications.

2513-76-0

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2513-76-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 2513-76-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,5,1 and 3 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 2513-76:
(6*2)+(5*5)+(4*1)+(3*3)+(2*7)+(1*6)=70
70 % 10 = 0
So 2513-76-0 is a valid CAS Registry Number.
InChI:InChI=1/C15H22O3/c1-9-5-4-8-15(3)13(18-15)12-11(7-6-9)10(2)14(16)17-12/h5,10-13H,4,6-8H2,1-3H3/t10-,11-,12-,13-,15+/m0/s1

2513-76-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name (Z)-1a,5,8-trimethyl-2,3,6,7,7a,8,10a,10b-octahydrooxireno[2',3':9,10]cyclodeca[1,2-b]furan-9(1aH)-one

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2513-76-0 SDS

2513-76-0Downstream Products

2513-76-0Relevant academic research and scientific papers

Microbial transformation of parthenolide

Galal, Ahmed M.,Ibrahim, Abdel-Rahim S.,Mossa, Jaber S.,El-Feraly, Farouk S.

, p. 761 - 765 (1999)

Microbial transformation of the germacranolide parthenolide using Rhizopus nigricans, Streptomyces fulvissimus and Rhodotorula rubra yielded three new compounds: 11αH-dihydroparthenolide, 9β-hydroxy-11βH- dihydroparthenolide and 14-hydroxy-11βH-dihydroparthenolide. 11βH- dihydroparthenolide was the only common metabolite produced by all microorganisms.

Aminoparthenolides as novel anti-leukemic agents: Discovery of the NF-κB inhibitor, DMAPT (LC-1)

Neelakantan, Sundar,Nasim, Shama,Guzman, Monica L.,Jordan, Craig T.,Crooks, Peter A.

body text, p. 4346 - 4349 (2010/04/05)

A series of aminoparthenolide analogs (6-37) were synthesized and evaluated for their anti-leukemic activity. Eight compounds exhibited good anti-leukemic activity with LD50's in the low μM range (1.5-3.0 μM). Compounds 16, 24 and 30 were the m

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