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Usage

Uses

Used in Pharmaceutical Industry:
1-(2-chlorophenyl)-2,2,2-trifluoroethanol is used as an intermediate for the synthesis of various pharmaceutical compounds, leveraging its ability to serve as a building block in organic synthesis. Its presence in the development of new drug molecules is crucial, as it can contribute to the creation of effective treatments for a range of medical conditions.
Used in Agrochemical Industry:
In the agrochemical sector, 1-(2-chlorophenyl)-2,2,2-trifluoroethanol is utilized as an intermediate in the production of agrochemicals, which are essential for enhancing crop protection and yield. Its role in this industry is vital for the development of innovative and effective products that can address various agricultural challenges.
Used in Antimicrobial Agents Development:
1-(2-chlorophenyl)-2,2,2-trifluoroethanol is used as a potential antimicrobial agent due to its demonstrated antimicrobial activity. It can be incorporated into formulations aimed at combating microbial infections, contributing to the development of new treatments and preventive measures against various pathogens.

Upstream product

• 2923-18-4 sodium 2,2,2-trifluoroacetate 
• 89-98-5 2-chloro-benzaldehyde 
• 426-58-4 (trifluoromethylsulfonyl)benzene 
• 81290-20-2 (trifluoromethyl)trimethylsilane 

Downstream Products

• 351002-89-6 1-(2-amino-5-phenyl)-2,2,2-trifluoroethanone 

Relevant academic research and scientific papers

Visible light-promoted umpolung coupling of aryl tri-/difluoroethanones with 2-alkenylpyridines

Tertiary alcohols bearing a trifluoromethyl group are of considerable medicinal interest. Using an umpolung strategy, we herein report the first intermolecular reductive cross-coupling of aryl tri-/difluoroethanones with 2-alkenylpyridines with the aid of a Br?nsted acid catalyst upon visible-light irradiation. This metal-free reaction is operationally simple and performed at ambient temperature, allowing access to desired tertiary alcohols with tri-/difluoromethyl groups in moderate to excellent yields. The commercially available and easily handled Hantzsch ester effectively serves as an electron donor, as well as a hydrogen atom source.

Highly efficient synthesis of aryl and heteroaryl trifluoromethyl ketones via o-iodobenzoic acid (IBX)

A two-step process for the synthesis of aryl and heteroaryl trifluoromethyl ketones from the corresponding aldehydes is described. Trifluoromethyl alcohols were prepared from aryl and heteroaryl aldehydes in excellent yields using catalytic amount of K2CO3. The trifluoromethyl alcohols were then oxidized conveniently and efficiently by o-iodoxybenzoic acid (IBX) under mild conditions to get the desired functionalized aryl and heteroaryl trifluoromethyl ketones.

Magnesium metal-mediated reductive trifluoromethylation of aldehydes with phenyl trifluoromethyl sulfone

An unprecedented reductive nucleophilic trifluoromethylation of aldehydes by using phenyl trifluoromethyl sulfone is reported. Mercury(II) chloride efficiently activates magnesium metal to induce the desulfonylative trifluoromethylation process. The new r

Sodium trifluoroacetate: An efficient precursor for the trifluoromethylation of aldehydes

In a convenient and efficient procedure, the nucleophilic trifluoromethylation of aldehydes with sodium trifluoroacetate was achieved, using copper(I) halides as the catalyst.

Process for the condensation of a carbonyl compound with an aromatic derivative in a basic medium

A process for condensing at least one carbonyl compound carrying at least one electron-withdrawing group with an aromatic derivative carrying at least one hydroxyl functional group, wherein the electron-withdrawing group present on the carbonyl compound i