351002-89-6

Basic information

• Product Name: Ethanone, 1-(2-aminophenyl)-2,2,2-trifluoro- (9CI)
• Synonyms: Ethanone, 1-(2-aminophenyl)-2,2,2-trifluoro- (9CI);2-(Trifluoroacetyl)aniline, 1-(2-Aminophenyl)-2,2,2-trifluoroethan-1-one;2'-Amino-2,2,2-trifluoroacetophenone;1-(2-AMinophenyl)-2,2,2-trifluoroethan-1-one
• CAS NO: 351002-89-6
• Molecular Formula: C₈H₆F₃NO
• Molecular Weight: 189.1345496
• Product Categories: ACETYLHALIDE
• Mol File: 351002-89-6.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethanone, 1-(2-aminophenyl)-2,2,2-trifluoro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(2-aminophenyl)-2,2,2-trifluoro- (9CI)(351002-89-6)
• EPA Substance Registry System: Ethanone, 1-(2-aminophenyl)-2,2,2-trifluoro- (9CI)(351002-89-6)

Safety Data

• Hazardous Substances Data: 351002-89-6(Hazardous Substances Data)

Usage

General Description

Ethanone, 1-(2-aminophenyl)-2,2,2-trifluoro-, also known as 1-(2-aminophenyl)-2,2,2-trifluoroethanone, is a chemical compound with the molecular formula C8H7F3NO. It is a trifluorinated ketone derivative with a substituted amino group attached to a phenyl ring. Ethanone, 1-(2-aminophenyl)-2,2,2-trifluoro- (9CI) is used in the fields of organic synthesis and medicinal chemistry, where it can be used as a building block for the synthesis of various pharmaceuticals and agrochemicals. Its trifluoromethyl group makes it a valuable reagent in the development of fluorinated pharmaceutical compounds, which have unique pharmacokinetic and metabolic properties. This chemical is primarily used in research and development, and it is important to handle and use it according to proper safety guidelines and regulations.

Upstream product

• 154598-53-5 1-(2-amino-5-chloro-phenyl)-2,2,2-trifluoro-ethanone 
• 1150561-03-7 N-[2-(trifluoroacetyl)phenyl]-2,2-dimethylpropionamide 
• 17408-17-2 2,2,2-trifluoro-1-(2-nitrophenyl)ethanone 
• 700362-32-9 2,2,2-trifluoro-1-(2-nitrophenyl) ethanol 
• 552-89-6 2-nitro-benzaldehyde 
• 615-36-1 2-bromoaniline 
• 65854-92-4 N-(2-bromophenyl)-2,2-dimethylpropanamide 
• 407-25-0 trifluoroacetic anhydride 
• 1885-29-6 anthranilic acid nitrile 
• 6625-74-7 N-pivaloylaniline 
• 124004-74-6 α-(trifluoromethyl)-2-fluorobenzenemethanol 
• 5860-95-7 1-(2-chlorophenyl)-2,2,2-trifluoroethan-1-one 
• 124004-75-7 α,α,α-trifluoro-2-fluoroacetophenone 
• 251352-64-4 1-(2-chlorophenyl)-2,2,2-trifluoroethanol 

Downstream Products

• 1034136-39-4 C₁₆H₁₈F₃NO₂S₂ 
• 1162717-96-5 N-(2-(trifluoroacetyl)phenyl)-3,5-dinitrobenzamide 

Relevant articles and documents

ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASES ASSOCIATED WITH P13K MODULATION

The disclosure relates to compounds of Formula (I) as allosteric chromenone inhibitors of phosphoinositide 3-kinase (PI3K) useful in the treatment of diseases or disorders associated with PI3K modulation, Formula (I), or a prodrug, solvate, enantiomer, st

ERBB/BTK INHIBITORS

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Phosphine-Catalyzed Intermolecular Annulations of Fluorinated ortho-Aminophenones with Alkynones – The Switchable [4+2] or [4+2]/[3+2] Cycloaddition

A phosphine-catalyzed intermolecular annulation reaction of functionalized ortho-aminoacetophenones with alkynones has been disclosed in this paper. A variety of 2-alkynylquinolines and benzo-fused indolizine were selectively afforded in moderate to good yields at different reaction temperatures and with different phosphine catalysts via the in situ generated zwitterionic intermediate derived from alkynone and phosphine. (Figure presented.).