251354-72-0

Upstream product

• 219783-80-9 7-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4-hydroxy-8-methyl-2H-1-benzopyran-2-one 
• 67973-49-3 4,7-dihydroxy-8-methyl-2H-1-benzopyran-2-one 
• 251354-71-9 4-(2-bromo-ethoxy)-7-(tert-butyl-diphenyl-silanyloxy)-8-methyl-chromen-2-one 

Downstream Products

• 251354-74-2 4-(2-Bromo-ethoxy)-3-chloro-7-((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyl-tetrahydro-pyran-2-yloxy)-8-methyl-chromen-2-one 
• 251354-73-1 4-(2-Bromo-ethoxy)-7-((2R,3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyl-tetrahydro-pyran-2-yloxy)-8-methyl-chromen-2-one 

Relevant academic research and scientific papers

Structure-activity relationship in two series of aminoalkyl substituted coumarin inhibitors of gyrase B

Two series of aminosubstituted coumarins were synthesised and evaluated in vitro as inhibitors of DNA gyrase and as potential antibacterials. Novel novobiocin-like coumarins, 4-(dialkylamino)-methylcoumarins and 4-((2-alkylamino)ethoxy)coumarins, were discovered as gyrase B inhibitors with promising antibacterial activity in vitro.