Structure-activity relationship in two series of aminoalkyl substituted coumarin inhibitors of gyrase B

Article abstract of DOI:10.1016/S0960-894X(99)00492-8

Two series of aminosubstituted coumarins were synthesised and evaluated in vitro as inhibitors of DNA gyrase and as potential antibacterials. Novel novobiocin-like coumarins, 4-(dialkylamino)-methylcoumarins and 4-((2-alkylamino)ethoxy)coumarins, were discovered as gyrase B inhibitors with promising antibacterial activity in vitro.