Structure-activity relationship in two series of aminoalkyl substituted coumarin inhibitors of gyrase B

DOI: 10.1016/S0960-894X(99)00492-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2875 - 2880 (1999)

Update date:2022-08-05

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Authors:

Laurin, Patrick

Ferroud, Didier

Schio, Laurent

Klich, Michael

Dupuis-Hamelin, Claudine

Mauvais, Pascale

Lassaigne, Patrice

Bonnefoy, Alain

Musicki, Branislav

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Article abstract of DOI:10.1016/S0960-894X(99)00492-8

Two series of aminosubstituted coumarins were synthesised and evaluated in vitro as inhibitors of DNA gyrase and as potential antibacterials. Novel novobiocin-like coumarins, 4-(dialkylamino)-methylcoumarins and 4-((2-alkylamino)ethoxy)coumarins, were discovered as gyrase B inhibitors with promising antibacterial activity in vitro.

Full text of DOI:10.1016/S0960-894X(99)00492-8

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