251658-58-9

Usage

Chemical Properties

Off-white solid

Upstream product

• 92288-94-3 2,4-dioxo-4-pyridin-3-ylbutyric acid ethyl ester 
• 2510-23-8 3-Ethynylpyridine 
• 623-73-4 diazoacetic acid ethyl ester 
• 350-03-8 methyl-3-pyridylketone 

Downstream Products

• 23424-35-3 5-(3-pyridyl)pyrazole-3-carboxylic acid hydrazide 
• 374064-01-4 3-(pyridin-3-yl)-1H-pyrazole-5-carboxylic acid 
• 287494-01-3 5-(pyridin-3-yl)-1H-pyrazole-3-carboxamide 
• 287494-03-5 (5-pyridin-3-yl-1H-pyrazol-3-yl)-methanol 

Relevant academic research and scientific papers

Synthesis, structure–activity relationships and biological evaluation of 4,5,6,7-tetrahydropyrazolopyrazines as metabotropic glutamate receptor 5 negative allosteric modulators

The design, synthesis and SAR studies of novel 4,5,6,7-tetrahydropyrazolopyrazines as metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulators (NAMs) are presented in this letter. Starting from a HTS hit compound (1, IC50?=?477

Three coordination polymers of transition metals built using HPPC ligand: Crystal structures and novel topology

A new pyrazole-carboxylate type ligand, 3-(pyridin-3-yl)-1H-pyrazole-5-carboxylic acid (HPPC) was prepared from 3-acetylpyridine, diethyl oxalate and hydrazine hydrate. By employing this ligand, three new coordination complexes were prepared under solvothermal conditions: {[Ni(PPC)2]·3H2O}n (1), [Ag(PPC)]n (2) and [Cd(PPC)Cl]n (3). Single-crystal X-ray diffraction analyses reveal that 1-3 exhibit three different structural types. Complex 1 displays a 4-connected net with the Schl?fli symbol (44·62) topology, several types of hydrogen bonds connect the 2-D layer to a 3-D structure. Complex 2 is built from [Ag(N2O)] clusters and PPC ligand as 3-connected linker with Schl?fli symbol {36·46·53} without consideration of Ag?Ag interaction. The 2-D networks are also linked to form 3 D framework via Ag?Ag interaction. Complex 3 can be regarded as a (3, 3)-connected net with the Schl?fli symbol {333·433}, which consists of [Cd(N2O2)] clusters and PPC ligand as 3-connected bridge. The layers are further linked by the cholride atoms to generate a 3-D network.

PYRAZOLE COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF DEGENERATIVE DISEASES AND DISORDERS

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful

NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE

The present invention relates to piperazine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.

A facile synthesis of pyrazoles with multi-point structural diversity by 1,3-dipolar cycloaddition

We describe the synthesis of diverse pyrazoles by 1,3-dipolar cycloaddition of ethyl diazoacetate with various acetylenes in refluxing toluene. The product pyrazoles are useful starting points for preparing a diverse collection of trisubstituted pyrazole

Substituted 1-(4-aminophenyl)pyrazoles and their use as anti-inflammatory agents

1-(4-aminophenyl)pyrazoles optionally substituted on the 3- and 5-positions of the pyrazole ring and on the amino group at the 4-position of the phenyl ring are disclosed and described, which pyrazoles inhibit IL-2 production in T-lymphocytes.

Synthesis and structure - Activity relationships of quarternary ammonium cephalosporins with 3-pyrazolylpyridium derivatives

Cephalosporins with 3-pyazolylpyridinium at C-3 position, which is supposed to exhibit synergic activity of ceftazidime and cefoselis, were synthesized and their antibacterial activity against Gram-positive and Gram-negative was inspected. (C) 2000 Elsevier Science Ltd. All rights reserved.