92288-94-3

Upstream product

• 350-03-8 methyl-3-pyridylketone 
• 95-92-1 oxalic acid diethyl ester 

Downstream Products

• 374064-01-4 3-(pyridin-3-yl)-1H-pyrazole-5-carboxylic acid 
• 251658-58-9 3-(pyridin-3-yl)-1H-pyrazole-5-carboxylic acid ethyl ester 
• 251658-58-9 ethyl 3-(3-pyridyl)pyrazole-5-carboxylate 
• 774218-44-9 2-(3-cyano-phenyl)-5-pyridin-3-yl-2H-pyrazole-3-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

PYRAZOLYL-BASED CARBOXAMIDES AS CRAC INHIBITORS

The invention relates to pyrazolyl-based carboxamide compounds useful as ICRAC inhibitors, to pharmaceutical compositions containing these compounds and to these compounds for the use in the treatment and/or prophylaxis of diseases and/or disorders, in particular inflammatory diseases and/or inflammatory disorders.

Three coordination polymers of transition metals built using HPPC ligand: Crystal structures and novel topology

A new pyrazole-carboxylate type ligand, 3-(pyridin-3-yl)-1H-pyrazole-5-carboxylic acid (HPPC) was prepared from 3-acetylpyridine, diethyl oxalate and hydrazine hydrate. By employing this ligand, three new coordination complexes were prepared under solvothermal conditions: {[Ni(PPC)2]·3H2O}n (1), [Ag(PPC)]n (2) and [Cd(PPC)Cl]n (3). Single-crystal X-ray diffraction analyses reveal that 1-3 exhibit three different structural types. Complex 1 displays a 4-connected net with the Schl?fli symbol (44·62) topology, several types of hydrogen bonds connect the 2-D layer to a 3-D structure. Complex 2 is built from [Ag(N2O)] clusters and PPC ligand as 3-connected linker with Schl?fli symbol {36·46·53} without consideration of Ag?Ag interaction. The 2-D networks are also linked to form 3 D framework via Ag?Ag interaction. Complex 3 can be regarded as a (3, 3)-connected net with the Schl?fli symbol {333·433}, which consists of [Cd(N2O2)] clusters and PPC ligand as 3-connected bridge. The layers are further linked by the cholride atoms to generate a 3-D network.

NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE

The present invention relates to piperazine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.

Discovery of α,γ-Diketo Acids as Potent Selective and Reversible Inhibitors of Hepatitis C Virus NS5b RNA-Dependent RNA Polymerase

α,γ-Diketo acids (DKA) were discovered from screening as selective and reversible inhibitors of hepatitis C virus NS5b RNA-dependent RNA polymerase. The diketo acid moiety proved essential for activity, while substitution on the γ position was necessary for selectivity and potency. Optimization led to the identification of a DKA inhibitor of NS5b polymerase with IC50 = 45 nM, one of the most potent HCV NS5b polymerase inhibitors reported.