251660-12-5

Basic information

• Product Name: (R)-3-phenylpentanoic acid ethyl ester
• Synonyms: (R)-3-phenylpentanoic acid ethyl ester
• CAS NO: 251660-12-5
• Molecular Weight: 206.285
• Mol File: 251660-12-5.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: (R)-3-phenylpentanoic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-phenylpentanoic acid ethyl ester(251660-12-5)
• EPA Substance Registry System: (R)-3-phenylpentanoic acid ethyl ester(251660-12-5)

Safety Data

• Hazardous Substances Data: 251660-12-5(Hazardous Substances Data)

Upstream product

• 1528-59-2 3-phenyl-pent-2-enoic acid ethyl ester 
• 93-55-0 1-phenyl-propan-1-one 
• 621-82-9 Cinnamic acid 
• 91427-14-4 3-phenylpentanoyl chloride 
• 2845-27-4 3-phenylpentanoic acid 
• 67478-54-0 ethyl 3-ethyl-3-phenylpropionate 
• 5292-53-5 diethyl benzalmalonate 
• 24410-84-2 ethyl (2E)-pentenoate 
• 1528-59-2 ethyl (E)-3-phenylpent-2-enoate 
• 29743-74-6 ethyl (E)-3-phenyl-2-pentenoate 

Downstream Products

• 5669-17-0 (R) 3-phenylvaleric acid 

Relevant articles and documents

Asymmetric CuH-catalyzed 1,4-reductions in water at room temperature

Taking advantage of micellar catalysis in water, asymmetric hydrosilylation reactions can now be conducted at ambient temperatures using water, and only water, as the global medium. Georg Thieme Verlag Stuttgart · New York.

Pyrrolidine-Based P,O Ligands from Carbohydrates: Easily Accessible and Modular Ligands for the Ir-Catalyzed Asymmetric Hydrogenation of Minimally Functionalized Olefins

The potential of P,O-iminosugar based ligands in the Ir-catalyzed asymmetric hydrogenation of minimally functionalized olefins is presented. These new ligands were prepared from easily available carbohydrates (D-mannose, D-ribose and D-arabinose). The stereochemical and polyfunctional diversity of carbohydrates allowed the modulation of the ligands, both from their electronic properties and the rigidity of their backbone. High enantioselectivities (ee’s up to 99 %) can be reached in the hydrogenation of selected tri- and disubstituted substrates.

Chiral ferrocene-based P,S ligands for Ir-catalyzed hydrogenation of minimally functionalized olefins. Scope and limitations

A family of 12 modular ferrocenyl planar chiral phosphine-thioethers (P,S) has been studied in the asymmetric hydrogenation of minimally functionalized alkenes. These ligands differ by the substituent on sulfur or by the linker between the ferrocene moiety and the sulfur atom (no linker, methylene or methyl substituted methylene linker bearing an additional element of chirality). The cationic iridium(cod) complexes of the different P,S ligands have been efficiently synthesized. For the majority of the ligands, coordination yielded only a single diastereoisomer with full control of the absolute configuration on sulfur. The different iridium complexes have been used in the hydrogenation of various di, tri, and tetrasubstituted minimally functionalized olefins. Conversions and enantioselectivities are highly dependent on the ligand and substrate structure. Full conversions and low-to-excellent enantioselectivities could be obtained (maximum ee from 14 to 94% for 1,1-disubsituted alkenes, from 17 to 99% for trisubstituted olefins, and 34% for the tetrasubstituted alkene).