25173-35-7

Usage

Uses

Used in Cosmetic Industry:
2-Methoxyhydrocinnamic acid is used as an active ingredient in skincare products for its antioxidant, antimicrobial, and anti-inflammatory properties. It helps treat various skin conditions and reduces the effects of aging by protecting the skin from oxidative stress and inflammation.
Used in Food Industry:
2-Methoxyhydrocinnamic acid is used as a food additive for its ability to preserve and stabilize ingredients. It extends the shelf life of food products and maintains their quality by preventing oxidation and spoilage.
Used in Pharmaceutical Industry:
2-Methoxyhydrocinnamic acid is used as a therapeutic agent for its potential health benefits, including protection against cardiovascular disease and cancer. Its antioxidant properties help neutralize free radicals and reduce inflammation, contributing to overall health and well-being.

InChI:InChI=1/C10H12O3/c1-8-4-2-3-5-9(8)13-7-6-10(11)12/h2-5H,6-7H2,1H3,(H,11,12)

Upstream product

• 57-57-8 β-Propiolactone 
• 4549-72-8 sodium o-cresolate 
• 25268-05-7 3-(2-methylphenoxy)propanenitrile 
• 107-94-8 chloropropionic acid 
• 95-48-7 ortho-cresol 
• 107-13-1 acrylonitrile 

Downstream Products

• 49660-56-2 8-methylchroman-4-one 
• 92865-29-7 3-<2-Aethoxycarbonyl-phenoxy>-propionsaeure-aethylester 
• 90918-59-5 3-<2-Carbamoyl-phenoxy>-propionamid 
• 3722-72-3 8-methyl-chroman 
• 65017-39-2 8-methyl-4H-1-benzopyran-4-one 
• 90921-10-1 acide chromannone-4 carboxylique-8 
• 64381-35-7 3-o-Tolyloxy-propionic acid (3,5-dimethyl-4-methylsulfanyl-phenoxycarbonylamino)-methyl ester 
• 64381-30-2 3-o-Tolyloxy-propionic acid (2,6-dichloro-phenoxycarbonylamino)-methyl ester 
• 64381-22-2 3-o-Tolyloxy-propionic acid (2,4-dichloro-phenoxycarbonylamino)-methyl ester 
• 64381-09-5 3-o-Tolyloxy-propionic acid (naphthalen-1-yloxycarbonylamino)-methyl ester 
• 64381-14-2 3-o-Tolyloxy-propionic acid (2-chloro-phenoxycarbonylamino)-methyl ester 

Relevant academic research and scientific papers

Acid activated montmorillonite K-10 mediated intramolecular acylation: Simple and convenient synthesis of 4-chromanones

3-Aryloxyproionic acids undergo intramolecular cyclization in the presence of AA.Mont.K-10 in toluene under reflux for 30–45 min in good to excellent yields. Phenyl ring bearing various substituents at the ortho, meta, para positions undergo this cyclization reaction. This method involves simple work up and amenable for large scale preparations. The heterogeneous acid treated catalyst can be regenerated and used for up to three cycles with minimum loss of activity.

Copper-Catalyzed Asymmetric Hydroboration of 2 H-Chromenes Using a Chiral Diphosphine Ligand

A highly regioselective asymmetric hydroboration of 2H-chromenes catalyzed by the complex of CuCl and diphosphine ligand (S,R)-DuanPhos has been realized under mild conditions to produce 3-boryl chromans, achieving good yields and excellent enantioselectivities up to 96% ee. This work provides an efficient approach to the synthesis of chiral 3-boryl chromans and derivatives.

Efficient and rapid synthesis of phenolic analogs of 4-phenylbutanoic acid using microwave-assisted Michael addition as a key reaction

ABSTRACT: The addition of phenols to acrylonitrile in the presence of aqueous benzyltrimethylammonium hydroxide or tetramethylammonium hydroxide under microwave irradiation yielded the corresponding Michael adducts. The obtained adducts were easily transformed to phenolic analogs of 4-phenylbutanoic acids via the hydrolysis of nitrile groups.

Synthesis, evaluation and in silico molecular modeling of pyrroyl-1,3,4-thiadiazole inhibitors of InhA

Enoyl acyl carrier protein reductase (ENR) is an essential type II fatty acid synthase (FAS-II) pathway enzyme that is an attractive target for designing novel antitubercular agents. Herein, we report sixty-eight novel pyrrolyl substituted aryloxy-1,3,4-thiadiazoles synthesized by three-step optimization processes. Three-dimensional quantitative structure-activity relationships (3D-QSAR) were established for pyrrolyl substituted aryloxy-1,3,4-thiadiazole series of InhA inhibitors using the comparative molecular field analysis (CoMFA). Docking analysis of the crystal structure of ENR performed by using Surflex-Dock in Sybyl-X 2.0 software indicates the occupation of pyrrolyl substituted aryloxy 1,3,4-thiadiazole into hydrophobic pocket of InhA enzyme. Based on docking and database alignment rules, two computational models were established to compare their statistical results. The analysis of 3D contour plots allowed us to investigate the effect of different substituent groups at different positions of the common scaffold. In vitro testing of ligands using biological assays substantiated the efficacy of ligands that were screened through in silico methods.

SYNTHESIS OF PROPYL PHENOXY ETHERS AND USE AS DELIVERY AGENTS

The present invention provides propyl phenoxy ether compounds and pharmaceutically acceptable salts thereof, compositions containing the same and one or more active agents, and methods of administering active agents with the same. The delivery agents of the present invention are well suited for forming non-covalent mixtures with active agents for oral, iπtracolonic, pulmonary, and other routes of administration to animals.

NOUVEAUX DERIVES DE LA BENZOPYRANNONE-4, A ACTIVITES ANALGESIQUE, ANTI-INFLAMMATOIRE ET ANTIAGREGANTE PLAQUETTAIRE

A series of 35 new derivatives of 3-benzylidene benzopyran-4-one carboxylic acid was synthesized; their antiinflammatory and analgesic activities were investigated and compared with those of acetylsalicylic acid, phenylbutazone, ketoprofene and glafenine.Among these compounds, four were found to be more potent than the references compounds in tests of antiinflammatory and analgesic activity.Seven compounds were tested on rat blood platelet aggregation induced by ADP.From these tests, HD-039, HD-041, HD-044 and HD-049 appear to be promising antiinflammatory, analgesic and anticlotting agents, although this original series shows little structural analogy with classical non-steroidal antiinflammatory agents.