251922-46-0

Usage

Uses

Used in Pharmaceutical Industry:
3-Oxetaneethanol is used as a chemical intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and medicines.
Used in Perfumery and Flavoring Industry:
3-Oxetaneethanol is used as a solvent and a component in perfumes and flavorings, enhancing the stability and effectiveness of these products.
Used in Organic Chemistry:
3-Oxetaneethanol is used as a valuable building block in organic chemistry, mediating the synthesis of a wide range of organic compounds and facilitating innovative chemical reactions.

Upstream product

• 1310381-54-4 2-(oxetan-3-yl) acetic acid 
• 569678-80-4 toluene-4-sulfonic acid 4-benzyloxy-2-hydroxymethyl-butyl ester 
• 77661-80-4 2-(2-(benzyloxy)ethyl)propane-1,3-diol 
• 41478-45-9 Diethyl<(2-benzyloxy)ethyl>malonate 
• 569678-81-5 3-(2-(benzyloxy)ethyl)oxetane 

Downstream Products

• 124391-75-9 -(+)-3-hydroxymethyltetrahydrofuran 
• 1135039-66-5 2-(oxetan-3-yl)ethyl 4-methylbenzenesulfonate 

Relevant academic research and scientific papers

Nonclassical Phenyl Bioisosteres as Effective Replacements in a Series of Novel Open-Source Antimalarials

The replacement of one chemical motif with another that is broadly similar is a common method in medicinal chemistry to modulate the physical and biological properties of a molecule (i.e., bioisosterism). In recent years, bioisosteres such as cubane and bicyclo[1.1.1]pentane (BCP) have been used as highly effective phenyl mimics. Herein, we show the successful incorporation of a range of phenyl bioisosteres during the open-source optimization of an antimalarial series. Cubane (19) and closo-carborane (23) analogues exhibited improved in vitro potency against Plasmodium falciparum compared to the parent phenyl compound; however, these changes resulted in a reduction in metabolic stability; unusually, enzyme-mediated oxidation was found to take place on the cubane core. A BCP analogue (22) was found to be equipotent to its parent phenyl compound and showed significantly improved metabolic properties. While these results demonstrate the utility of these atypical bioisosteres when used in a medicinal chemistry program, the search to find a suitable bioisostere may well require the preparation of many candidates, in our case, 32 compounds.

METHOD OF CONTROLLING LACTATE PRODUCTION WITH PIPERDINE-DIONE DERIVATIVES

The invention provides novel compounds having the general formula: and tautomers and pharmaceutically acceptable salts thereof, wherein A1, A2, A3, A4, R1, R4, R5, R6, R7 and R8 are as defined herein, compositions including the compounds and methods of using the compounds.

PIPERIDINE-DIONE DERIVATIVES

The invention provides novel compounds having the general formula (I) and tautomers and pharmaceutically acceptable salts thereof, wherein A1, A2, A3, A4, R1, R4, R5, R6, R7 and R8 are as defined herein, compositions including the compounds and methods of using the compounds.

NEW POSITIVE ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTOR

The present invention relates to indole derivatives useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said com- pounds. The compounds referred to are positive allosteric modulators (PAMs) of the nicotinic acetylcholine α7 receptor.

Synthesis of extremely simplified compounds possessing the key pharmacophore units of taxol, phenylisoserine and oxetane moieties

Straight chain compounds having a phenylisoserine unit and an oxetane ring at the α- and ω- position, respectively as extremely simplified analogues of taxol were prepared. None of these compounds showed promising tubulin inhibitory activity.