251992-72-0Relevant academic research and scientific papers
Cell adhesion-inhibiting antiinflammatory compounds
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, (2008/06/13)
Compounds having Formula I are useful for treating inflammation. Also disclosed are pharmaceutical compositions comprising compounds of Formula I, and methods of inhibiting/treating inflammatory diseases in a mammal.
Discovery of inhibitors of cell adhesion molecule expression in human endothelial cells. 1. Selective inhibition of ICAM-1 and E-selectin expression
Stewart,Bhatia,McCarty,Patel,Staeger,Arendsen,Gunawardana,Melcher,Zhu,Boyd,Fry,Cool,Kiflie,Lartey,Marsh,Kempf-Grote,Kilgannon,Wisdom,Meyer,Gallatin,Okasinskit
, p. 988 - 1002 (2007/10/03)
A critical early event in the inflammatory cascade is the induced expression of cell adhesion molecules on the lumenal surface of vascular endothelial cells. These adhesion molecules include E-selectin, ICAM-1, and VCAM-1, which serve to recruit circulati
