252006-19-2

Upstream product

• 252006-18-1 (2R,3E,5S,6S,7S,8R)-6-(tert-butyldimethylsilyloxymethyl)-1,9-di(tert-butyldiphenylsilyloxy)-7-(3,4-dimethoxybenzyloxy)-2,4,8-trimethyl-3-nonen-5-ol 
• 252006-15-8 tert-Butyl-{(R)-2-[(4S,5S)-2-(3,4-dimethoxy-phenyl)-5-vinyl-[1,3]dioxan-4-yl]-propoxy}-diphenyl-silane 
• 240821-01-6 (2S,3S,4R)-5-tert-butyldiphenylsilyloxy-4-methyl-2-vinylpentane-1,3-diole 
• 240821-04-9 (2E,4R)-5-(tert-butyldiphenylsilyloxy)-2-iodo-4-methyl-2-pentene 
• 91751-24-5 (R)-3-[(tert-butyldiphenylsilyl)oxy]-2-methylpropanal 
• 92817-88-4 (2S)-3-{[tert-butyl(diphenyl)silyl]oxy}-2-methylpropanal 
• 3282-30-2 pivaloyl chloride 
• 240821-12-9 (2R,3E,5S,6S,7S,8R)-1,9-di(tert-butyldiphenylsilyloxy)-6-hydroxymethyl-7-(3,4-dimethoxybenzyloxy)-2,4,8-trimethyl-3-nonen-5-ol 
• 194610-23-6 (R)-tert-butyl((4,4-dibromo-2-methylbut-3-en-1-yl)oxy)diphenylsilane 
• 194610-24-7 (4R)-5-(tert-butyldiphenylsilyloxy)-4-methyl-2-pentyne 
• 240821-06-1 (2R,3E,6S,7S,8R)-6-(tert-butyldimethylsilyloxymethyl)-1,9-di(tert-butyldiphenylsilyloxy)-7-(3,4-dimethoxybenzyloxy)-2,4,8-trimethyl-3-nonen-5-one 
• 240821-10-7 (2R,3E,6S,7S,8R)-1,9-di(tert-butyldiphenylsilyloxy)-6-hydroxymethyl-7-(3,4-dimethoxybenzyloxy)-2,4,8-trimethyl-3-nonen-5-one 
• 252006-14-7 3-(tert-butyl-dimethyl-silanyloxymethyl)-6-(tert-butyl-diphenyl-silanyloxy)-4-(3,4-dimethoxy-benzyloxy)-5-methyl-hexane-1,2-diol 
• 240821-03-8 (3S,4S,5R)-3-(tert-butyldimethylsilyloxymethyl)-6-(tert-butyldiphenylsilyloxy)-4-(3,4-dimethoxybenzyloxy)-5-methyl-1-hexene 

Relevant academic research and scientific papers

Synthetic studies of an 18-membered antitumor macrolide, tedanolide. 5. Stereoselective synthesis of the C13 - C23 part via condensation of two fragments, C13 - C17 and C18 - C21, by taking advantage of the 3,4- dimethoxybenzyl protecting group

An efficient and stereoselective synthesis of the C13 - C23 part (8) was achieved starting from methyl (R) - and (S)-3-hydroxy-2-methylpropionates (9) via coupling of the C13 - C17 aldehyde (6), prepared by Evans asymmetric aldol reaction, with the C18 - C21 iodoalkene (5b) by taking advantage of the 3,4-dimethoxybenzyl protecting group.