2,2-Dimethyl-propionic acid (E)-(2R,3S,6R)-7-(tert-butyl-diphenyl-silanyloxy)-2-[(1S,2R)-3-(tert-butyl-diphenyl-silanyloxy)-1-(3,4-dimethoxy-benzyloxy)-2-methyl-propyl]-3-hydroxy-4,6-dimethyl-hept-4-enyl ester

Base Information

Chemical Name:2,2-Dimethyl-propionic acid (E)-(2R,3S,6R)-7-(tert-butyl-diphenyl-silanyloxy)-2-[(1S,2R)-3-(tert-butyl-diphenyl-silanyloxy)-1-(3,4-dimethoxy-benzyloxy)-2-methyl-propyl]-3-hydroxy-4,6-dimethyl-hept-4-enyl ester
CAS No.:252006-19-2
Molecular Formula:C₅₉H₈₀O₈Si₂
Molecular Weight:973.45
Hs Code.:

2,2-Dimethyl-propionic acid (E)-(2R,3S,6R)-7-(tert-butyl-diphenyl-silanyloxy)-2-[(1S,2R)-3-(tert-butyl-diphenyl-silanyloxy)-1-(3,4-dimethoxy-benzyloxy)-2-methyl-propyl]-3-hydroxy-4,6-dimethyl-hept-4-enyl ester

Synonyms:2,2-Dimethyl-propionic acid (E)-(2R,3S,6R)-7-(tert-butyl-diphenyl-silanyloxy)-2-[(1S,2R)-3-(tert-butyl-diphenyl-silanyloxy)-1-(3,4-dimethoxy-benzyloxy)-2-methyl-propyl]-3-hydroxy-4,6-dimethyl-hept-4-enyl ester

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Chemical Property of 2,2-Dimethyl-propionic acid (E)-(2R,3S,6R)-7-(tert-butyl-diphenyl-silanyloxy)-2-[(1S,2R)-3-(tert-butyl-diphenyl-silanyloxy)-1-(3,4-dimethoxy-benzyloxy)-2-methyl-propyl]-3-hydroxy-4,6-dimethyl-hept-4-enyl ester

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Technology Process of 2,2-Dimethyl-propionic acid (E)-(2R,3S,6R)-7-(tert-butyl-diphenyl-silanyloxy)-2-[(1S,2R)-3-(tert-butyl-diphenyl-silanyloxy)-1-(3,4-dimethoxy-benzyloxy)-2-methyl-propyl]-3-hydroxy-4,6-dimethyl-hept-4-enyl ester

There total 24 articles about 2,2-Dimethyl-propionic acid (E)-(2R,3S,6R)-7-(tert-butyl-diphenyl-silanyloxy)-2-[(1S,2R)-3-(tert-butyl-diphenyl-silanyloxy)-1-(3,4-dimethoxy-benzyloxy)-2-methyl-propyl]-3-hydroxy-4,6-dimethyl-hept-4-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.5%

: 3282-30-2
pivaloyl chloride

: 240821-12-9
(2R,3E,5S,6S,7S,8R)-1,9-di(tert-butyldiphenylsilyloxy)-6-hydroxymethyl-7-(3,4-dimethoxybenzyloxy)-2,4,8-trimethyl-3-nonen-5-ol

: 252006-19-2
2,2-Dimethyl-propionic acid (E)-(2R,3S,6R)-7-(tert-butyl-diphenyl-silanyloxy)-2-[(1S,2R)-3-(tert-butyl-diphenyl-silanyloxy)-1-(3,4-dimethoxy-benzyloxy)-2-methyl-propyl]-3-hydroxy-4,6-dimethyl-hept-4-enyl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 ℃; for 1.5h;
DOI:10.1248/cpb.47.1288

Reference yield:

: (2R,3E,6S,7S,8R)-6-(tert-butyldimethylsilyloxymethyl)-1,9-di(tert-butyldiphenylsilyloxy)-7-(3,4-dimethoxybenzyloxy)-2,4,8-trimethyl-3-nonen-5-ol

: 252006-19-2
2,2-Dimethyl-propionic acid (E)-(2R,3S,6R)-7-(tert-butyl-diphenyl-silanyloxy)-2-[(1S,2R)-3-(tert-butyl-diphenyl-silanyloxy)-1-(3,4-dimethoxy-benzyloxy)-2-methyl-propyl]-3-hydroxy-4,6-dimethyl-hept-4-enyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / Dess-Martin periodinane; pyridine / CH₂Cl₂ / 1 h / 20 °C

2: 99 percent / PPTS / ethanol / 6 h / 50 - 55 °C

3: 96 percent / Zn(BH₄)2 / diethyl ether / 7 h / 0 °C

4: 87.5 percent / Et₃N; DMAP / CH₂Cl₂ / 1.5 h / 0 °C

With pyridine; dmap; zinc(II) tetrahydroborate; pyridinium p-toluenesulfonate; Dess-Martin periodane; triethylamine; In diethyl ether; ethanol; dichloromethane; 1: Oxidation / 2: Hydrolysis / 3: Hydrogenolysis / 4: Condensation;
DOI:10.1248/cpb.47.1288

Reference yield:

: 240821-06-1
(2R,3E,6S,7S,8R)-6-(tert-butyldimethylsilyloxymethyl)-1,9-di(tert-butyldiphenylsilyloxy)-7-(3,4-dimethoxybenzyloxy)-2,4,8-trimethyl-3-nonen-5-one

: 252006-19-2
2,2-Dimethyl-propionic acid (E)-(2R,3S,6R)-7-(tert-butyl-diphenyl-silanyloxy)-2-[(1S,2R)-3-(tert-butyl-diphenyl-silanyloxy)-1-(3,4-dimethoxy-benzyloxy)-2-methyl-propyl]-3-hydroxy-4,6-dimethyl-hept-4-enyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / PPTS / ethanol / 6 h / 50 - 55 °C

2: 96 percent / Zn(BH₄)2 / diethyl ether / 7 h / 0 °C

3: 87.5 percent / Et₃N; DMAP / CH₂Cl₂ / 1.5 h / 0 °C

With dmap; zinc(II) tetrahydroborate; pyridinium p-toluenesulfonate; triethylamine; In diethyl ether; ethanol; dichloromethane; 1: Hydrolysis / 2: Hydrogenolysis / 3: Condensation;
DOI:10.1248/cpb.47.1288