25209-64-7

Usage

Derived from

Piperazine

Type of compound

Heterocyclic amine

Usage

Synthesis of pharmaceutical drugs and chemical building block

Structural features

Piperazine ring, aldehyde group, 2-hydroxyethyl group attached to the fourth carbon

Common use

Production of pharmacological agents

Known for

Modifying pharmacokinetics and pharmacodynamics of bioactive compounds

Importance

Key intermediate in the synthesis of pharmaceuticals and other biologically active molecules.

Upstream product

• 103-76-4 1-(2-hydroxyethyl)piperazine 
• 107-31-3 Methyl formate 
• 68-12-2 N,N-dimethyl-formamide 
• 100747-87-3 5-methyl-2-thioxo-1,3,4-thiadiazole-3(2H)-carbaldehyde 

Downstream Products

• 351343-88-9 4-(2-(piperazin-1-yl)ethoxy)benzonitrile 
• 561023-88-9 4-(2-((1H-benzo[d]imidazol-2-yl)thio)ethyl)piperazine-1-carbaldehyde 
• 552336-64-8 2-(2-Cyanophenoxy)ethylpiperazine 
• 351343-89-0 1-[2-(3-cyanophenoxy)ethyl]piperazine 

Relevant academic research and scientific papers

PROCESS FOR PRODUCTION OF 1- 2-(BENZIMIDAZOL-2-YL- THIO)ETHYL ]PIPERAZINE OR SALTS THEREOF

This invention relates to a method for producing 1-[2-(benzimidazol-2-ylthio)ethyl]piperadine (5) or its salt by the following reaction scheme:This invention enables efficient production of 1-[2-(benzimidazol-2-ylthio)ethyl]piperadine or its salt which is an intermediate in the production of a cyclic diamine compound which is useful as a ACAT inhibitor.

Formylpiperazinyl-(meth)acrylic acid derivatives for treatment of collagen

The invention relates to new formylpiperazine group-containing (meth)acrylic acid esters and (meth)acrylamides (I) of the general formula (L) STR1 in which R1 is hydrogen or methyl, R2 is a divalent aliphatic or cycloaliphatic radical, and X is --O-- or --NH--, and to preparations which contain these compounds, for use as adhesive component for the treatment of collagen-containing materials, and to processes for the preparation and to the use of the preparations.

A NEW FORMYLATION REAGENT: 4-FORMYL-2-METHYL-1,3,4-THIADIAZOLIN-5-THIONE

4-Formyl-2-methyl-1,3,4-thiadiazolin-5-thione, prepared from acetic formic anhydride, is found to act as a selective formylation reagent under mild conditions.The synthesis of some N-formyl antibiotics with this reagent is reported.