252210-02-9Relevant academic research and scientific papers
BIVALENT TARGETED CONJUGATES
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, (2020/05/28)
The invention provides conjugates that comprise a bivalent targeting moiety, a nucleic acid, and optional linking groups as well as synthetic intermediates and synthetic methods useful for preparing the conjugates, compositions comprising the bidentate targeting ligands and the conjugates, as well as methods for targeting therapeutic nucleic acids with the bidentate conjugates. The conjugates are useful to target therapeutic nucleic acids.
THERAPEUTIC METHODS
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, (2020/05/28)
The invention provides methods and compositions for delivering a nucleic acid to a cell or the cytosol of the target cell. The method includes contacting the cell with, 1) a membrane-destabilizing polymer; and 2) a nucleic acid conjugate. The nucleic acid conjugate includes a targeting ligand bound to an optional linker and a nucleic acid.
Peptide dendrimers with designer core for directed self-assembly
Verma, Ram P.,Shandilya, Ashutosh,Haridas
, p. 8758 - 8765 (2015/10/20)
A series of designer peptide dendrimers with urea and urea-triazole cores were synthesized. Urea cored dendrimers assembled into fibrillar morphology, while dendrimers with urea-triazole core assembled into vesicular morphology. The core-dependent self-as
Multi-tier dendrimers with an aromatic core
Haridas,Sharma, Yogesti K.,Naik, Sarala
body text, p. 1570 - 1577 (2009/07/11)
We report various multi-tier designer dendritic molecules that incorporate an aromatic core and heterocyclic and peptide units. The 5-(azidomethyl)benzene- 1,3-dicarbonyl unit was chosen as the scaffold as this unit allows two identical units and a reacti
Phenylglycinamide and pyridylglycinamide derivatives useful as anticoagulants
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Page/Page column 56, (2010/11/25)
The present invention provides novel phenylglycinamide derivatives of Formula (I) or (IV): or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein the variables W, W1, Y, Z, R7, R8, R9, and R11 are as defined herein. These compounds are selective inhibitors of factor VIIa which can be used as medicaments.
On the meaning of affinity: Cluster glycoside effects and concanavalin a
Dimick, Sarah M.,Powell, Steven C.,McMahon, Stephen A.,Moothoo, Davina N.,Naismith, James H.,Toone, Eric J.
, p. 10286 - 10296 (2007/10/03)
The inhibition of protein - carbohydrate interaction provides a powerful therapeutic strategy for the treatment of myriad human diseases. To date, application of such approaches have been frustrated by the inherent low affinity of carbohydrate ligands for
