252210-01-8Relevant academic research and scientific papers
BIVALENT TARGETED CONJUGATES
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Page/Page column 59; 60, (2020/05/28)
The invention provides conjugates that comprise a bivalent targeting moiety, a nucleic acid, and optional linking groups as well as synthetic intermediates and synthetic methods useful for preparing the conjugates, compositions comprising the bidentate targeting ligands and the conjugates, as well as methods for targeting therapeutic nucleic acids with the bidentate conjugates. The conjugates are useful to target therapeutic nucleic acids.
THERAPEUTIC METHODS
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Page/Page column 204; 231-232, (2020/05/28)
The invention provides methods and compositions for delivering a nucleic acid to a cell or the cytosol of the target cell. The method includes contacting the cell with, 1) a membrane-destabilizing polymer; and 2) a nucleic acid conjugate. The nucleic acid conjugate includes a targeting ligand bound to an optional linker and a nucleic acid.
Radiolabeled Dibenzodiazepinone-Type Antagonists Give Evidence of Dualsteric Binding at the M2 Muscarinic Acetylcholine Receptor
Pegoli, Andrea,She, Xueke,Wifling, David,Hübner, Harald,Bernhardt, Günther,Gmeiner, Peter,Keller, Max
supporting information, p. 3314 - 3334 (2017/05/05)
The dualsteric ligand approach, aiming at ligands with improved subtype selectivity, has been increasingly applied to muscarinic receptors (MRs). In this article, we present the synthesis and characterization of a M2R subtype-preferring radiola
Hybrid materials based on novel 2D lanthanide coordination polymers covalently bonded to amine-modified SBA-15 and MCM-41: assembly, characterization, structural features, thermal and luminescence properties
Wang, Jun,Dou, Wei,Kirillov, Alexander M.,Liu, Weisheng,Xu, Cailing,Fang, Ran,Yang, Lizi
supporting information, p. 18610 - 18621 (2016/12/03)
Three novel 2D coordination polymers [Tb2(μ4-L)2(μ-HL)(μ-HCOO)(DEF)]n (Tb-L), [Eu(μ4-L)(L)(H2O)2]n (Eu-L), and [Nd(μ4-L)(L)(H2O)2]sub
Peptide dendrimers with designer core for directed self-assembly
Verma, Ram P.,Shandilya, Ashutosh,Haridas
supporting information, p. 8758 - 8765 (2015/10/20)
A series of designer peptide dendrimers with urea and urea-triazole cores were synthesized. Urea cored dendrimers assembled into fibrillar morphology, while dendrimers with urea-triazole core assembled into vesicular morphology. The core-dependent self-as
Non-aqueous pigmented inkjet inks
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Page/Page column 29, (2012/03/27)
A non-aqueous inkjet ink includes C.I. Pigment Yellow 150 and a polymeric dispersant according to Formula (I): wherein, T represents hydrogen or a polymerization terminating group; Z represents the residue of polyethyleneimine having a number-average mole
Multi-tier dendrimers with an aromatic core
Haridas,Sharma, Yogesti K.,Naik, Sarala
body text, p. 1570 - 1577 (2009/07/11)
We report various multi-tier designer dendritic molecules that incorporate an aromatic core and heterocyclic and peptide units. The 5-(azidomethyl)benzene- 1,3-dicarbonyl unit was chosen as the scaffold as this unit allows two identical units and a reacti
On the meaning of affinity: Cluster glycoside effects and concanavalin a
Dimick, Sarah M.,Powell, Steven C.,McMahon, Stephen A.,Moothoo, Davina N.,Naismith, James H.,Toone, Eric J.
, p. 10286 - 10296 (2007/10/03)
The inhibition of protein - carbohydrate interaction provides a powerful therapeutic strategy for the treatment of myriad human diseases. To date, application of such approaches have been frustrated by the inherent low affinity of carbohydrate ligands for
