252259-67-9Relevant academic research and scientific papers
Inhibitors of farnesyl protein transferase
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, (2008/06/13)
The present invention comprises benzodiazepine compounds having farnesyl transferase inhibitory activity.
Discovery and structure-activity relationships of imidazole-containing tetrahydrobenzodiazepine inhibitors of farnesyltransferase
Ding, Charles Z.,Batorsky, Roberta,Bhide, Rajeev,Chao, Hannguang J.,Cho, Young,Chong, Saeho,Gullo-Brown, Johnni,Guo, Peng,Kim, Soong Hoon,Lee, Frank,Leftheris, Katerina,Miller, Arthur,Mitt, Toomas,Patel, Manorama,Penhallow, Becky A.,Ricca, Carol,Rose, William C.,Schmidt, Robert,Slusarchyk, William A.,Vite, Gregory,Yan, Ning,Manne, Veeraswamy,Hunt, John T.
, p. 5241 - 5253 (2007/10/03)
2,3,4,5-Tetrahydro-1-(imidazol-4-ylalkyl)-1,4-benzodiazepines were found to be potent inhibitors of farnesyltransferase (FT). A hydrophobic substituent at the 4-position of the benzodiazepine, linked via a hydrogen bond acceptor, was important to enzyme i
