25249-16-5

Usage

Uses

Used in Biomedical Applications:
pHEMA is used as a nonadhesive substrate in the preparation of single cell suspensions to implant into mice cornea for corneal micropocket assays. It is also used to coat well plates for sphere assays using adipose-derived mesenchymal stem cells.
Used in Tissue Engineering:
pHEMA scaffolds are used in tissue engineering, where they can be utilized in hydrogels for biomedical applications and as sorbents for metal ions.
Used in Ophthalmology:
pHEMA has been used in the development of soft contact lenses, providing a comfortable and effective alternative to traditional hard lenses.
Used in Drug Delivery Systems:
pHEMA is employed in drug delivery systems, where it can be used to control the release of medications and improve their efficacy.
Used in Medical Devices:
pHEMA has been utilized in the production of kidney dialysis membranes, offering improved biocompatibility and performance.
Used in Controlled Drug Delivery:
Nanoparticles of pHEMA may be employed as a carrier for controlled delivery of anticancer and antitumor drugs, enhancing the therapeutic outcomes and reducing side effects.
Used in Different Industries:
In the biomedical industry, pHEMA is used as a versatile material for various applications, including tissue engineering, drug delivery systems, and medical devices.
In the ophthalmology industry, pHEMA is used in the development of soft contact lenses, providing a comfortable and effective alternative to traditional hard lenses.

Biochem/physiol Actions

Poly(2-hydroxyethyl methacrylate) is an acrylic compound and has dental usage. It is mainly used to inhibit cell adhesion to growth surfaces in culture vessels.

InChI:InChI=1/C6H10O3/c1-5(2)6(8)9-4-3-7/h7H,1,3-4H2,2H3

Upstream product

• 75-21-8 oxirane 
• 79-41-4 poly(methacrylic acid) 
• 107-21-1 ethylene glycol 
• 920-46-7 Methacryloyl chloride 
• 463-49-0 1,2-propanediene 
• 201230-82-2 carbon monoxide 
• 2421-28-5 dianhydride of benzophenone-3,4,3',4'-tetracarboxy acid 
• 80-62-6 methacrylic acid methyl ester 
• 21282-97-3 2-(methacryloyloxy)ethyl acetoacetate 
• 1269794-11-7 2,2-(2-nitro-1,4-phenylene)bis(methylene)bis(oxy) bis(oxomethylene)bis(oxy)bis(ethane-2,1-diyl) bis(2-methylacrylate) 
• 20166-49-8 2-acetoxyethyl methylacrylate 
• 1279115-97-7 C₂₃H₄₅NO₁₀P₂ 
• 1279115-96-6 C₁₈H₃₅NO₁₀P₂ 
• 67-56-1 methanol 

Downstream Products

• 1338495-88-7 1,3,5-tri(2-hydroxyethyl)isocyanurate tris-HEMA phthalate 

Relevant academic research and scientific papers

BIOGUM AND BOTANICAL GUM HYDROGEL BIOINKS FOR THE PHYSIOLOGICAL 3D BIOPRINTING OF TISSUE CONSTRUCTS FOR IN VITRO CULTURE AND TRANSPLANTATION

Bioink compositions comprising a biomaterial (mammalian, plant based, synthetically derived, or microbially derived) such as a hydrogel and a microbial-, fungal-, or plant-produced polysaccharide, with or without cells, for use in the 3D bioprinting of human tissues and scaffolds are described. The bioink compositions have excellent printability and improved cell function, viability and engraftment. Furthermore, the bioink compositions can be supplemented through the additional of auxiliary proteins and other molecules such as growth factors including extracellular matrix components, Laminins, super affinity growth factors and morphogens. The bioink compositions can be used under physiological conditions related to 3D bioprinting parameters which are cytocompatible (e.g. temperature, printing pressure, nozzle size, bioink gelation process). The combination of a biogum-based biomaterial together with mammalian, plant, microbial or synthetically derived hydrogels exhibited improvement in printability, cell function and viability compared to tissues printed with bioink not containing biogums.

Acrylate monomer having hydrophilic end group and a method for preparing the same

More particularly, the present invention relates to an acrylate monomer having a high-purity hydrophilic terminal group which does not contain unreacted 1 water or undesirable by-products, and a method for producing the acrylate monomer. These acrylate monomers are substantially free of polymerization inhibitors. Chemical Formula 1. In Chemical Formula 1, R. 1 Chem. R. 2 Chem. R. 3 May be H, or linear, branched or cyclic C, independently of each other. 1 -C12 alkyl group. R4 Is linear, branched or cyclic C. 1 -C12 alkyl Or C1 -C12 It is alkoxy group, wherein alkyl group carbon atoms can be unsubstituted or substituted with oxygen atoms, n Is an integer selected from 1 and 10.

Runge-Kutta analysis for optimizing the Zn-catalyzed transesterification conditions of MA and MMA with diols to maximize monoesterified products

Terminal hydroxylated acrylates and methacrylates were prepared by catalytic transesterification of acrylates and methacrylates with diols catalyzed by a system of a tetranuclear zinc alkoxide, [Zn(tmhd)(OMe)(MeOH)]4 (1a), with 4 equiv. of 2,2′-bipyridine (L1). The reaction time to reach the equilibrium state was analyzed by kinetic studies and a curve-fitting analysis based on the Runge-Kutta method for optimizing the best reaction conditions for mono-esterification. In addition to these kinetic analyses, DFT calculations estimated a proposed mechanism of the catalytic transesterification. This journal is

Method for producing hydroxyethyl methacrylate through ester exchange method

The invention discloses a method for producing hydroxyethyl methacrylate through an ester exchange method, and belongs to a chemical synthesis method. The method comprises the following steps: using methyl methacrylate and ethylene glycol as raw materials, using p-toluene sulfonic acid as a catalyst, using phenothiazine as a polymerization inhibitor, and performing a reaction under the condition of the temperature of 100-120 DEG C so as to prepare a target product. The method disclosed by the invention is safe and simple; compared with catalysts of hexadecyl trimethyl ammonium hydroxide, potassium cyanide, heavy metallic salt type catalysts and the like, the catalyst used in the method disclosed by the invention, namely the p-toluene sulfonic acid, is lower in price, easier to obtain, easier to store and use, smaller in pollution, and better in cooperation use effect with the polymerization inhibitor, and the method is easy in industrialization application.

METHOD FOR PREPARING HYDROXYETHYL (METH) ACRYLATE

Hydroxyethyl (methyl)acrylate is prepared by a process of a combination of a three-stage tubular reactor and a tower reactor, wherein, firstly, a catalyst, a polymerization inhibitor and (methyl) acrylic acid are mixed until the solids are dissolved, then mixed with a part of ethylene oxide and thereafter enter into a first tubular reactor for a reaction, a reaction liquid flowing out from the first tubular reactor is mixed with a certain amount of ethylene oxide and enters into a second tubular reactor for a reaction, a reaction liquid flowing out from the second tubular reactor is then mixed with a certain amount of ethylene oxide and thereafter enters into a third tubular reactor, and a reaction liquid flowing out from the third tubular reactor is then passed through a stage of an adiabatic tower reactor and aged such that a product liquid is obtained from extraction.

Preparation technique of high-purity hydroxyethyl methacrylate

The invention provides a preparation technique of high-purity hydroxyethyl methacrylate. A rectification process is added in a purification process; a polymerization inhibitor is replenished through a spraying way in a phase transformation process of the rectification process; meanwhile, the vacuum degree and the working temperature of a tower top are controlled; the flash polymerization, in a rectifying tower, of the hydroxyethyl methacrylate is avoided, so as to achieve the purposes of being stable in operation, being capable of effectively preventing polymerization and improving product quality, thereby improving the purity of a hydroxyethyl methacrylate product.

HYDROXYALKYL (METH)ACRYLATE AND METHOD FOR PRODUCING SAME

The objective of the present invention is to provide a highly stable hydroxyalkyl (meth)acrylate. The hydroxyalkyl (meth) acrylate according to the present invention is characterized in that a contained amount of dialkylene glycol is not more than 0.05 mass%.

METHOD FOR PRODUCING IRON CARBONATE

The purpose of the present invention is to provide a method for producing an iron carbonate, whereby it becomes possible to prevent the generation of hydrogen during the production of the iron carbonate by the reaction of a carboxylic acid with metal iron. An embodiment of the present invention is a method for producing an iron carbonate by reacting metal iron with a carboxylic acid in a reaction solution, wherein a compound of trivalent iron is added to the reaction solution, the reaction solution contains a compound of trivalent iron at the time of the start of the reaction, the reaction solution contains a non-iron metal having a standard electrode potential of -2.5 to 0.1 inclusive or a metal compound containing the metal, or the reaction solution contains at least one metal selected from the group consisting of Ag, Bi and Pd or a metal compound containing the metal.

PROCESSES FOR PRODUCTION OF IRON METHACRYLATE AND HYDROXYALKYL METHACRYLATE

There is provided a method for producing iron methacrylate being inexpensive, and being high in activity and selectivity and good in solubility to a reaction liquid when being used in production of a hydroxyalkyl methacrylate as a catalyst. The method for producing iron methacrylate for production of a hydroxyalkyl methacrylate according to the present invention includes subjecting a mixture of a metallic iron having an oxygen atom content by XRF analysis of the surface thereof of 6% by mass or lower, and methacrylic acid to a heat treatment at 95°C or higher and lower than 110°C for 100 to 600 min. The method for producing a hydroxyalkyl methacrylate according to the present invention includes reacting an alkylene oxide with methacrylic acid to produce the hydroxyalkyl methacrylate, wherein iron methacrylate produced by the method according to the present invention is used as a catalyst.

Synthesis of fullerene-containing methacrylates

The Bingel-Hirsch reaction between fullerene C60 and 2-methacryloyloxyethyl methyl malonate or 2-methacryloyloxyethyl dichloroacetate afforded the corresponding monocyclopropanation products.