252558-51-3

Upstream product

• 252558-59-1 (R)-5-[(tert-butyldiphenylsilyl)oxy]-4-ethyl-1-pentanol 
• 252558-58-0 tert-butyl-(2-ethyl-pent-4-enyloxy)-diphenyl-silane 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 89790-39-6 (2R)-2-Ethyl-4-penten-1-ol 
• 252558-49-9 methanesulfonic acid 4-(tert-butyl-diphenyl-silanyloxymethyl)-hexyl ester 

Downstream Products

• 252558-52-4 (3S,7R)-7-(tert-Butyl-diphenyl-silanyloxymethyl)-3-methyl-nonan-2-one 
• 252558-53-5 (4R,5R,8S,12R)-1-Azido-12-(tert-butyl-diphenyl-silanyloxymethyl)-4-ethyl-5-hydroxy-8-methyl-tetradecan-7-one 
• 252558-61-5 (4R,5R,8S,12R)-1-Azido-12-(tert-butyl-diphenyl-silanyloxymethyl)-4-ethyl-5-methoxymethoxy-8-methyl-tetradecan-7-one 

Relevant academic research and scientific papers

Enantioselective Total Synthesis of Fluvirucinin B1

A convergent synthesis of fluvirucinin B1 from acid ent-6a and nitrile ent-9, involving an organocopper coupling, a stereoselective allylation, a ring-closing metathesis reaction, and a stereoselective hydrogenation as the key steps, is reported. The starting building blocks have been prepared in a straightforward manner from a common phenylglycinol-derived lactam 1. An unprecedented regioselective oxidation of phenylglycinol-derived secondary amines 5 to carboxylic acids 6 has been developed.

High-yielding enantioselective synthesis of the macrolactam aglycon of Sch 38516 from two units of (2R)-2-ethyl-4-penten-1-ol

The same precursor - namely, (2R)-2-ethyl-4-penten-1-ol - was used to obtain fragments C9-C13 and C1-C8 of 1, the aglycon of Sch 38516 (which is active against Candida sp.) and fluvirucin B1 (which is active against influenza A virus). The key