252561-45-8Relevant academic research and scientific papers
EIF4E INHIBITORS AND USES THEREOF
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Paragraph 00289, (2020/03/29)
The present invention provides compounds inhibiting elF4E activity, and compositions and methods of using thereof. Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful for treating a variety of diseases, dis
IMPROVED COMPOUNDS FOR MYC INHIBITION
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Page/Page column 15, (2020/02/06)
There is disclosed a compound, a pharmaceutical composition and a method of cancer treatment with an improved Myc inhibitor compound. More specifically, there is disclosed an improved compound having with improved solubility, improved binding characterist
Synthetic molecules for disruption of the MYC protein-protein interface
Jacob, Nicholas T.,Miranda, Pedro O.,Shirey, Ryan J.,Gautam, Ritika,Zhou, Bin,de Orbe Izquierdo, M. Elena,Hixon, Mark S.,Hart, Jonathan R.,Ueno, Lynn,Vogt, Peter K.,Janda, Kim D.
supporting information, p. 4234 - 4239 (2018/07/25)
MYC is a key transcriptional regulator involved in cellular proliferation and has established roles in transcriptional elongation and initiation, microRNA regulation, apoptosis, and pluripotency. Despite this prevalence, functional chemical probes of MYC
DIAGNOSTIC AND REMEDY FOR DISEASE CAUSED BY AMYLOID AGGREGATION AND/OR DEPOSITION
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Page/Page column 23, (2008/12/07)
To provide a diagnostic drug which binds specifically to an amyloid aggregate and/or an amyloid deposit, to thereby realize imaging and quantification of a disease caused by amyloid aggregation and/or deposition. The invention provides a compound represented by formula (1) : (wherein X1 represents an optionally substituted bicyclic heterocyclic group; X2 represents a hydrogen atom, a halogen atom, or a chelate-forming group; ring A represents a benzene ring or a pyridine ring; and ring B represents an optionally substituted 5-membered aromatic heterocyclic group which is bonded to the benzene ring or the pyridine ring via a carbon atom of ring B), a salt thereof, a solvate of any of these, or a transition metal coordination compound of any of these, and a diagnostic, preventive, or therapeutic drug containing the same.
