252574-03-1

Basic information

• Product Name: (3S,4S)-N-Boc-3-(benzylamino)-4-hydroxypyrrolidine
• Synonyms: (3s,4s)-n-boc-3-(benzylamino)-4-hydroxypyrrolidine;(3S,4S)-3-Hydroxy-4-[(phenylmethyl)amino]-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester;(3S,4S)-tert-Butyl 3-(benzylamino)-4-hydroxypyrrolidine-1-carboxylate;hydroxypyrrolidine-1-carboxylate;(3S,4S)-N-Boc-3-(benzylamino)-4-hydroxypyrrolidine-4;tert-butyl (3S,4S)-3-(benzylamino)-4-hydroxypyrrolidine-1-carboxylate
• CAS NO: 252574-03-1
• Molecular Formula: C₁₆H₂₄N₂O₃
• Molecular Weight: 292.37
• Mol File: 252574-03-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 424.6°C at 760 mmHg
• Flash Point: 210.6°C
• Appearance: /
• Density: 1.16
• Vapor Pressure: 5.77E-08mmHg at 25°C
• Refractive Index: 1.564
• Storage Temp.: 2-8°C(protect from light)
• PKA: 14.24±0.40(Predicted)
• CAS DataBase Reference: (3S,4S)-N-Boc-3-(benzylamino)-4-hydroxypyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: (3S,4S)-N-Boc-3-(benzylamino)-4-hydroxypyrrolidine(252574-03-1)
• EPA Substance Registry System: (3S,4S)-N-Boc-3-(benzylamino)-4-hydroxypyrrolidine(252574-03-1)

Safety Data

• Hazardous Substances Data: 252574-03-1(Hazardous Substances Data)

Usage

General Description

(3S,4S)-N-Boc-3-(benzylamino)-4-hydroxypyrrolidine is a chemical compound that belongs to the class of pyrrolidine derivatives. It is a chiral compound with a Boc group attached to the nitrogen atom and a benzylamino group attached to the third carbon of the pyrrolidine ring. The compound also contains a hydroxyl group at the fourth carbon of the pyrrolidine ring. (3S,4S)-N-Boc-3-(benzylamino)-4-hydroxypyrrolidine has potential applications in organic synthesis, medicinal chemistry, and chemical biology due to its unique structure and chiral nature. It can be used as a building block for the synthesis of more complex molecules or as a starting material for the development of new pharmaceuticals.

InChI:InChI=1/C16H24N2O3/c1-16(2,3)21-15(20)18-10-13(14(19)11-18)17-9-12-7-5-4-6-8-12/h4-8,13-14,17,19H,9-11H2,1-3H3/t13-,14-/m0/s1

Upstream product

• 114214-49-2 1-tert-butoxycarbonyl-3,4-epoxypyrrolidine 
• 252574-02-0 (±)-trans-tert-butyl 3-bromo-4-hydroxypyrrolidine-1-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 4248-19-5 tert-butyl carbazate 
• 252574-04-2 (3S,4S)-3-benzylamino-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester (+)-mandelic acid salt 
• 73286-70-1 N-(tert-butoxycarbonyl)-3-pyrroline 

Downstream Products

• 190792-74-6 (3S,4S)-4-amino-1-N-tert-butyloxycarbonyl-3-hydroxypyrrolidine 
• 859213-33-5 (3S,4S)-tert-butyl 3-(dimethyl amino)-4-hydroxypyrrolidine-1-carboxylate 
• 1009075-43-7 (3S,4S)-tert-butyl 3-amino-4-fluoropyrrolidine-1-carboxylate 
• 1174020-30-4 cis-3-amino-4-fluoropyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Asymmetric Synthesis of cis -(S, R)-3-Amino-4-fluoro-1-methylpyrrolidine

The development of the stereoselective synthesis of cis -(S, R)-3-amino-4-fluoro-1-methylpyrrolidine is described starting from chiral, non-racemic 1-[(3 S,4 S)-3-azido-4-hydroxypyrrolidin-1-yl]-2,2,2-trifluoroethan-1-one. Two sets of deoxyfluorination co

MINERALOCORTICOID RECEPTOR ANTAGONISTS AND METHODS OF USE

The present invention provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising a compound of Formula (I) in combination with a suitable carrier, diluent, or excipient; and methods for treating physiological disorders, particularly congestive heart failure, hypertension, diabetic nephropathy, or chronic kidney disease, comprising administering a compound of Formula (I), or a pharmaceutically acceptable salt thereof.