252578-36-2Relevant academic research and scientific papers
Total synthesis of landomycins Q and R and related core structures for exploration of the cytotoxicity and antibacterial properties
Lai, Yao-Hsuan,Mondal, Soumik,Su, Hsin-Tzu,Huang, Sheng-Cih,Wu, Mine-Hsine,Huang,Yang Lauderdale, Tsai-Ling,Song, Jen-Shin,Shia, Kak-Shan,Mong, Kwok-Kong Tony
, p. 9426 - 9432 (2021/03/16)
Herein, we report the total synthesis of landomycins Q and R as well as the aglycone core, namely anhydrolandomycinone and a related core analogue. The synthesis features an acetate-assisted arylation method for construction of the hindered B-ring in the
Phenoxylpropanolamines, method for the production thereof and pharmaceutical compositions containing the same
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, (2008/06/13)
The invention concerns compounds of formula (Ia) wherein R1arepresents hydrogen, an —S(O)z—(C1-C4)Alk group, a —CO(C1-C4)Alk group, an —NHSO2—(C1-C4)Alk group, an NCHl (C1-C4) Alk group, a 2-furyl group or a halogen; R2represents hydrogen or a (C1-C4)Alk group, a (C1-C4) alkoxyl group, a halogen, —COOH, —COO(C1-C4)Alk, —CN, —CONR3R4, —NO2, —SO2NH2, —NHSO2(C1-C4)Alk; m and n are independently 0, 1 or 2; R3and R4independently represent hydrogen or a (C1-C4)Alk group; Z is 1 or 2 and their salts or solvates, the pharmaceutical compositions that contain them, the process for their preparation, and intermediate synthesis products.
