2527-59-5

Basic information

• Product Name: 2,2'-dithiobis[N-ethylbenzamide]
• Synonyms: 2,2'-dithiobis[N-ethylbenzamide]
• CAS NO: 2527-59-5
• Molecular Formula: C18H20N2O2S2
• Molecular Weight: 360.4936
• EINECS: 219-769-0
• Mol File: 2527-59-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 570.1°Cat760mmHg
• Flash Point: 298.6°C
• Appearance: /
• Density: 1.26g/cm³
• CAS DataBase Reference: 2,2'-dithiobis[N-ethylbenzamide](CAS DataBase Reference)
• NIST Chemistry Reference: 2,2'-dithiobis[N-ethylbenzamide](2527-59-5)
• EPA Substance Registry System: 2,2'-dithiobis[N-ethylbenzamide](2527-59-5)

Safety Data

• Hazardous Substances Data: 2527-59-5(Hazardous Substances Data)

Usage

General Description

2,2'-dithiobis[N-ethylbenzamide], also known as EDTA, is a chemical compound with the molecular formula C16H18N2O2S2. It is an organic compound that contains two benzamide groups connected by a dithiodiacetate linker. EDTA is commonly used as a chelating agent in various industrial and pharmaceutical applications. Its ability to bind metal ions makes it effective in sequestering metal contaminants in water treatment and other environmental remediation processes. Additionally, EDTA is also utilized in the production of certain medications and personal care products. Despite its widespread use, EDTA is known to be toxic to aquatic organisms and may have harmful effects on the environment if not properly managed.

Upstream product

• 19602-82-5 2,2'-dithiodibenzoic acid dichloride 
• 75-04-7 ethylamine 
• 80031-02-3 2-Bromo-N-ethylbenzamide 
• 119-80-2 2,2'-dithiobenzoic acid 
• 4299-06-3 2-Ethylbenzisothiazolin-3-on 
• 65382-84-5 2-Mercapto-N-ethyl-benzamid 

Downstream Products

• 4299-06-3 2-Ethylbenzisothiazolin-3-on 
• 65382-84-5 2-Mercapto-N-ethyl-benzamid 
• 18712-20-4 2-ethyl-1,2-benzisothiazol-3(2H)-one 1,1-dioxide 

Relevant articles and documents

Preparation method of chemical intermediate 2,2'-dithiobenzamide compound

The invention provides a preparation method of a chemical intermediate 2,2'-dithiobenzamide compound, which comprises the following steps: reacting a 2-substituted benzamide compound with a sulfur reagent in an aprotic solvent with a high boiling point under the combined action of a metal salt and a ligand to generate a 2,2'-dithiobenzamide compound. The 2,2'-dithiobenzamide compound provided by the invention is an important chemical intermediate, the synthetic process route is simple, and the pollution of three wastes to the environment is reduced while the cost is reduced.

A new class of anti-HIV-1 agents targeted toward the nucleocapsid protein NCp7: The 2,2'-dithiobisbenzamides

As part of the National Cancer Institute's Drug Screening Program, a new class of antiretrovirals active against the human immunodeficiency virus HIV-1 has been identified, and the HIV-1 nucleocapsid protein NCp7 was proposed as the target of antiviral action. The 2,2'-dithiobis-[4'-(sulfamoyl)benzanilide] (3x) and the 2,2'-dithiobis(5-acetylamino)benzamide (10) represented the prototypic lead structures. A wide variety of 2,2'-dithiobisbenzamides were prepared and tested for anti-HIV-1 activity, cytotoxicity, and their ability to extrude zinc from the zinc fingers for NCp7. The structure-activity relationships demonstrated that the ability to extrude zinc from NCp7 resided in the 2,2'-dithiobisbenzamide core structure. The 3,3' and the 4,4' isomers were inactive. While many analogs based upon the core structure retained the zinc extrusion activity, the best overall anti-HIV-1 activity was only found in a narrow set of derivatives possessing carboxylic acid, carboxamide, or phenylsulfonamide functional groups. These functional groups were more important for reducing cytotoxicity than improving antiviral potency or activity vs NCp7. All of the compounds with antiviral activity also extruded zinc from NCp7. From this study several classes of low μM anti-HIV agents with simple chemical structures were identified as possible chemotherapeutic agents for the treatment of AIDS.

DISPROPORTIONIERUNGEN VON DIPHENYLDISULFIDEN ZU 1.2-BENZISOTHIAZOLEN UND o-SUBSTITUIERTEN THIOPHENOLEN UNTER ANCHIMERER BETEILIGUNG VON ORTHOSTAENDIGEN AMID-, THIOAMID- UND AMIDIN-GRUPPEN

Substituents in the ortho position provide anchimeric support in the dissociation of diphenylsulphides.The carbamoyl group has only a weak effect.Support increases from an N,N'-disubstituted guanyl group, over thioamide to a guanyl group with an unsubstituted nitrogen atom, which effects an almost completely reversible cleavage of the disulphide group.