252875-48-2Relevant academic research and scientific papers
An efficient and green synthesis of 1,4-dihydropyridine derivatives through multi-component reaction in ionic liquid
Fan, Xue Sen,Li, Yan Zhen,Zhang, Xin Ying,Qu, Gui Rong,Wang, Jian Ji,Hu, Xue Yuan
, p. 382 - 388 (2006)
Through multi-component condensation of aldehydes, 1,3-dione, Meldrum's acid, and ammonium acetate in an ionic liquid ([bmim][BF4]), a series of 1,4-dihydropyridine derivatives were prepared in excellent yields in the absence of any additional
Synthesis and structural study of 3,4-dihydro-2(1H)-pyridones and isoazolo[5,4-b]pyridin-6(7H)-ones
Suarez, Margarita,Verdecia, Yamila,Ochoa, Estael,Salfran, Esperanza,Moran, Lourdes,Martin, Nazario,Martinez, Roberto,Quinteiro, Margarita,Seoane, Carlos,Soto, Jose L.,Novoa, Hector,Blaton, Norbert,Peeters, Oswald M.,De Ranter, Camiel
, p. 2079 - 2088 (2007/10/03)
A series of isoxazolo[5,4-b]pyridin-6(7H)-ones (8) have been prepared with a high stereochemical control from the novel 3,4-dihydro-2(1H)-pyridones (7) by reaction with hydroxylamine hydrochloride and subsequent 5-endo-trig cyclization. A structural study by X-ray analyses and theoretical calculations (AM1) of both heterocyclic systems (7 and 8) shows a favoured conformer with the aryl group on C4 in a pseudoaxial position. The same favoured conformation was found in solution according to NOE experiments and comparison of theoretical and experimental coupling constants.
