252931-41-2Relevant academic research and scientific papers
Bisphosphonate prodrugs: Synthesis and in vitro evaluation of novel acyloxyalkyl esters of clodronic acid
Niemi, Riku,Veps?l?inen, Jouko,Taipale, Hannu,J?rvinen, Tomi
, p. 5053 - 5058 (1999)
Novel tetra-, tri-, and P,P'-dipivaloyloxymethyl esters of clodronic acid were synthesized, and their properties as possible prodrugs of clodronate were evaluated in vitro. All pivaloyloxymethyl esters were significantly more lipophilic (log P(app) ranged
