252938-22-0 Usage
General Description
Dimethyl 2-(4-fluorobenzyl)malonate is an organic compound that belongs to the class of malonate esters. It is used in the synthesis of various pharmaceuticals and agrochemicals due to its ability to serve as a building block in organic synthesis. The compound is a clear, colorless liquid with a molecular weight of 240.235 g/mol. It is flammable and may cause irritation to the skin, eyes, and respiratory system upon exposure. Dimethyl 2-(4-fluorobenzyl)malonate is primarily used in the pharmaceutical industry for the preparation of potential drug candidates and intermediates.
Check Digit Verification of cas no
The CAS Registry Mumber 252938-22-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,5,2,9,3 and 8 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 252938-22:
(8*2)+(7*5)+(6*2)+(5*9)+(4*3)+(3*8)+(2*2)+(1*2)=150
150 % 10 = 0
So 252938-22-0 is a valid CAS Registry Number.
InChI:InChI=1/C12H13FO4/c1-16-11(14)10(12(15)17-2)7-8-3-5-9(13)6-4-8/h3-6,10H,7H2,1-2H3
252938-22-0Relevant articles and documents
Reductive Knoevenagel Condensation with the Zn-AcOH System
Ivanov, Konstantin L.,Melnikov, Mikhail Ya.,Budynina, Ekaterina M.
, p. 1285 - 1291 (2020/11/13)
An efficient gram-scale one-pot approach to 2-substituted malonates and related structures is developed, starting from commercially available aldehydes and active methylene compounds. The technique combines Knoevenagel condensation with the reduction of the C=C bond in the resulting activated alkenes with the Zn-AcOH system. The relative ease with which the C=C bond reduction occurs can be traced to the accepting abilities of the substituents in the intermediate arylidene malonates.
