25297-51-2

Usage

Uses

Used in Chemosensor Development:
2,6-DICHLORO-4-PHENYL-PYRIDINE is used as a lead structure for chemosensor development due to its potential to selectively interact with target analytes. Its molecular structure allows for the design of chemosensors that can detect and quantify specific chemical species, which is crucial in various analytical and diagnostic applications.

InChI:InChI=1/C11H7Cl2N/c12-10-6-9(7-11(13)14-10)8-4-2-1-3-5-8/h1-7H

Upstream product

• 98027-84-0 2,6-dichloro-4-iodopyridine 
• 28557-00-8 phenylzinc chloride 
• 108-86-1 bromobenzene 
• 2587-02-2 2,6-dichloro-[4]pyridylamine 
• 24388-23-6 2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole 
• 2402-78-0 2,6-dichloropyridine 
• 591-50-4 iodobenzene 
• 123-91-1 1,4-dioxane 
• 98027-80-6 4-bromo-2,6-dichloropyridine 
• 89402-43-7 5-chloro-2,3-difluoropyridine 
• 98-80-6 phenylboronic acid 
• 87486-37-1 3,5-dichloro-1-phenylpyrazin-2(1H)-one 
• 536-74-3 phenylacetylene 

Downstream Products

• 392658-01-4 2-benzyloxy-6-chloro-4-phenyl-pyridine 
• 1624605-34-0 (4S,6S)-4-(5-((6-chloro-4-phenylpyridin-2-yl)oxy)-2-fluorophenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine 
• 392658-03-6 trifluoro-methanesulfonic acid 6-(4-methoxy-2-methyl-phenyl)-4-phenyl-pyridin-2-yl ester 
• 392658-02-5 2-benzyloxy-6-(4-methoxy-2-methyl-phenyl)-4-phenyl-pyridine 
• 392658-04-7 4-phenylpyridin-2-yl trifluoromethanesulfonate 
• 19006-81-6 4-phenylpyridin-2-ol 
• 392657-97-5 2-chloro-6-(4-methoxy-2-methyl-phenyl)-4-phenyl-pyridine 

Relevant academic research and scientific papers

A telescoped Knochel-Hauser/Kumada-Corriu coupling strategy to functionalized aromatic heterocycles

The direct application of Knochel-Hauser derivative arylmagnesium halides in Kumada-Corriu couplings is described. By utilizing the in situ-generated Grignard reagents, the transmetalation with stoichiometric zinc salts to known Negishi coupling conditions is avoided, thereby streamlining the transformation. Several aromatic hetereocycles participate in the deprotonation and couple with a variety of phenyl iodides and bromides in isolated yields up to 81%. The parent system is demonstrated on 6 g scale with 79% yield, and monitored via ReactIR to show the stability of the Grignard and progression of the deprotonation/C–C coupling reaction.

Crystal Structure and Subsequent Ligand Design of a Nonriboside Partial Agonist Bound to the Adenosine A2AReceptor

In this study, we determined the crystal structure of an engineered human adenosine A2A receptor bound to a partial agonist and compared it to structures cocrystallized with either a full agonist or an antagonist/inverse agonist. The interaction between the partial agonist, belonging to a class of dicyanopyridines, and amino acids in the ligand binding pocket inspired us to develop a small library of derivatives and assess their affinity in radioligand binding studies and potency and intrinsic activity in a functional, label-free, intact cell assay. It appeared that some of the derivatives retained the partial agonist profile, whereas other ligands turned into inverse agonists. We rationalized this remarkable behavior with additional computational docking studies.

PERFLUORINATED 5,6-DIHYDRO-4H-1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE

The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A4, A5, A6, A8, each of R1 and R2, R3 and R7 of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas II and III, and sub-formula embodiments thereof, intermediates and processes and methods useful for the preparation of compounds of Formulas I-III.

Exploiting the versatile assembly of arylpyridine fluorophores for wavelength tuning and SAR

(Matrix presented) The facile modular assembly of polyarylpyridine fluorophores provides two important advantages in the development of fluorescent chemosensors: it allows rapid dissection of the structural requirements for fluorescent chemosensing and it allows dramatic tuning of emission wavelength by changes in a substituent remote from the binding site.

Convenient synthesis and transformation of 2,6-dichloro-4-iodopyridine

(Matrix Presented) We describe a convenient scalable synthesis of 2,6-dichloro-4-iodopyridine and demonstrate its utility by stepwise elaboration to a number of 2,4,6-trisubstituted pyridines.

DIELS-ALDER REACTIONS OF THE HETERODIENE SYSTEM IN 2(1H)-PYRAZINONES

Variously substituted 2(1H)-pyrazinones react with acetylenic derivatives to give specifically substituted pyridones or pyridines.The observed selectivity can be explained in terms of HO-LU interactions for the reagents and two competitive retro Diels-Ald