25297-51-2

Basic information

• Product Name: 2,6-DICHLORO-4-PHENYL-PYRIDINE
• Synonyms: 2,6-DICHLORO-4-PHENYL-PYRIDINE;4-Phenyl-2,6-dichloropyridine;(2,6-Dichloropyridin-4-yl)benzene;2,6-Dichloro-4-phenylpyridine 95%
• CAS NO: 25297-51-2
• Molecular Formula: C₁₁H₇Cl₂N
• Molecular Weight: 224.08598
• Mol File: 25297-51-2.mol
• Article Data: 6

Chemical Properties

• Melting Point: 50-51 °C(Solv: pentane (109-66-0))
• Boiling Point: 336.3°C at 760 mmHg
• Flash Point: 187.5°C
• Appearance: /
• Density: 1.304g/cm³
• Vapor Pressure: 0.000221mmHg at 25°C
• Refractive Index: 1.599
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: -2.77±0.10(Predicted)
• CAS DataBase Reference: 2,6-DICHLORO-4-PHENYL-PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-DICHLORO-4-PHENYL-PYRIDINE(25297-51-2)
• EPA Substance Registry System: 2,6-DICHLORO-4-PHENYL-PYRIDINE(25297-51-2)

Safety Data

• Hazardous Substances Data: 25297-51-2(Hazardous Substances Data)

Usage

Uses

2,6-Dichloro-4-phenylpyridine has been screened for potential as lead structure for chemosensor development.

InChI:InChI=1/C11H7Cl2N/c12-10-6-9(7-11(13)14-10)8-4-2-1-3-5-8/h1-7H

Upstream product

• 98027-84-0 2,6-dichloro-4-iodopyridine 
• 108-86-1 bromobenzene 
• 24388-23-6 2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole 
• 2402-78-0 2,6-dichloropyridine 
• 591-50-4 iodobenzene 
• 123-91-1 1,4-dioxane 
• 98027-80-6 4-bromo-2,6-dichloropyridine 
• 89402-43-7 5-chloro-2,3-difluoropyridine 
• 98-80-6 phenylboronic acid 
• 2587-02-2 2,6-dichloro-[4]pyridylamine 
• 28557-00-8 phenylzinc chloride 
• 87486-37-1 3,5-dichloro-1-phenylpyrazin-2(1H)-one 
• 536-74-3 phenylacetylene 

Downstream Products

• 392657-97-5 2-chloro-6-(4-methoxy-2-methyl-phenyl)-4-phenyl-pyridine 
• 19006-81-6 4-phenylpyridin-2-ol 
• 392658-04-7 4-phenylpyridin-2-yl trifluoromethanesulfonate 
• 392658-02-5 2-benzyloxy-6-(4-methoxy-2-methyl-phenyl)-4-phenyl-pyridine 
• 392658-03-6 trifluoro-methanesulfonic acid 6-(4-methoxy-2-methyl-phenyl)-4-phenyl-pyridin-2-yl ester 
• 1624605-34-0 (4S,6S)-4-(5-((6-chloro-4-phenylpyridin-2-yl)oxy)-2-fluorophenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine 
• 392658-01-4 2-benzyloxy-6-chloro-4-phenyl-pyridine 

Relevant articles and documents

A telescoped Knochel-Hauser/Kumada-Corriu coupling strategy to functionalized aromatic heterocycles

The direct application of Knochel-Hauser derivative arylmagnesium halides in Kumada-Corriu couplings is described. By utilizing the in situ-generated Grignard reagents, the transmetalation with stoichiometric zinc salts to known Negishi coupling conditions is avoided, thereby streamlining the transformation. Several aromatic hetereocycles participate in the deprotonation and couple with a variety of phenyl iodides and bromides in isolated yields up to 81%. The parent system is demonstrated on 6 g scale with 79% yield, and monitored via ReactIR to show the stability of the Grignard and progression of the deprotonation/C–C coupling reaction.

PERFLUORINATED 5,6-DIHYDRO-4H-1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE

The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A4, A5, A6, A8, each of R1 and R2, R3 and R7 of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas II and III, and sub-formula embodiments thereof, intermediates and processes and methods useful for the preparation of compounds of Formulas I-III.

Convenient synthesis and transformation of 2,6-dichloro-4-iodopyridine

(Matrix Presented) We describe a convenient scalable synthesis of 2,6-dichloro-4-iodopyridine and demonstrate its utility by stepwise elaboration to a number of 2,4,6-trisubstituted pyridines.