87486-37-1Relevant academic research and scientific papers
Synthesis and fungicidal activity of 3,5-dichloropyrazin-2(1H)-one derivatives
Francois, Isabelle E.J.A.,Cammue, Bruno P.A.,Bresseleers, Sara,Fleuren, Hein,Hoornaert, Georges,Mehta, Vaibhav P.,Modha, Sachin G.,Van der Eycken, Erik V.,Thevissen, Karin
supporting information; experimental part, p. 4064 - 4066 (2010/03/25)
We synthesized a family of 3,5-dichloropyrazin-2(1H)-one derivatives and assessed their in vitro fungicidal activity against Candida albicans. Compounds 11 and 20 were most active against C. albicans and induced accumulation of reactive oxygen species in
A straightforward microwave method for rapid synthesis of N-1, C-6 functionalized 3,5-dichloro-2(1H)-pyrazinones
Gising, Johan,Oertqvist, Pernilla,Sandstroem, Anja,Larhed, Mats
supporting information; experimental part, p. 2809 - 2815 (2009/09/07)
A rapid and versatile one-pot, 2 × 10 min microwave protocol for the preparation of N-1 and C-6 decorated 3,5-dichloro-2(1H)-pyrazinones was developed. Comparable reaction sequences using classical conditions require about 1-2 days of heating. The α-amino
A new synthesis of substituted 2(1H)-pyrazinones
Vekemans,Pollers Wieers,Hoornaert
, p. 919 - 923 (2007/10/02)
The hydrohalides of 2-sec-aminoalkanenitriles on treatment with oxalyl halides in o-dichlorobenzene at 80-100° give 3,5-dihalo-2(1H)-pyrazinones, of which the 3-halo substituent is easily replaced by nucleophiles. A reaction mechanism for the pyrazinone s
