19006-81-6

Usage

Uses

Used in Pharmaceutical Industry:
2-Hydroxy-4-phenylpyridine is used as a pharmaceutical intermediate for the development of new drugs due to its unique chemical structure, which can be modified to create compounds with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Hydroxy-4-phenylpyridine is used as a precursor in the synthesis of active ingredients for pesticides, leveraging its chemical reactivity and structural features to target specific pests or diseases.
Used in Material Science:
2-Hydroxy-4-phenylpyridine is utilized in material science as a component in the development of new materials with tailored properties, such as in the creation of organic dyes, sensors, or other functional materials where its specific interactions can be exploited.
Used in Organic Synthesis:
As a building block in organic synthesis, 2-Hydroxy-4-phenylpyridine is used for the construction of more complex organic molecules, providing a versatile starting point for the synthesis of a wide range of compounds with potential applications in various industries.
While the specific applications and reasons for using 2-Hydroxy-4-phenylpyridine in each industry are outlined above, it is important to note that ongoing research and development are essential to fully realize its potential and to ensure safe and effective use in various applications.

InChI:InChI=1/C11H9NO/c13-11-8-10(6-7-12-11)9-4-2-1-3-5-9/h1-8H,(H,12,13)

Upstream product

• 14371-10-9 (E)-3-phenylpropenal 
• 41220-29-5 N-carbamoylmethylpyridinium chloride 
• 40673-25-4 4-chloro-2-hydroxypyridine 
• 143-66-8 sodium tetraphenyl borate 
• 25297-51-2 2,6-dichloro-4-phenylpyridine 
• 98-80-6 phenylboronic acid 
• 1131-61-9 4-Phenylpyridine 1-oxide 
• 109-89-7 diethylamine 
• 107-91-5 cyanoacetic acid amide 
• 104-55-2 3-phenyl-propenal 
• 98027-84-0 2,6-dichloro-4-iodopyridine 
• 2587-02-2 2,6-dichloro-[4]pyridylamine 
• 392658-01-4 2-benzyloxy-6-chloro-4-phenyl-pyridine 

Downstream Products

• 1105690-62-7 ethyl 4-methyl-2-(2-oxo-4-phenylpyridin-1(2H)-yl)thiazole-5-carboxylate 
• 1312478-87-7 ethyl 2-methyl-2-(methylsulfonyl)-4-(2-oxo-4-phenylpyridin-1(2H)-yl)butanoate 
• 1312479-41-6 ethyl 2-ethyl-2-(methylsulfonyl)-4-(2-oxo-4-phenylpyridin-1(2H)-yl)butanoate 
• 127956-40-5 1-<2-cyano-1-(4-chlorophenyl)-ethenyl>4-phenyl-2(1H)-pyridinone 
• 127956-37-0 1-<2-cyano-1-(4-methoxyphenyl)-ethenyl>4-phenyl-2(1H)-pyridinone 
• 53698-46-7 2-methoxy-4-phenyl-pyridine 
• 67970-80-3 1-methyl-4-phenyl-2(1H)-pyridone 
• 37520-85-7 (1R,8R)-9-Methyl-11-phenyl-9-aza-tricyclo[6.2.2.0^2,7]dodeca-2⁽⁷⁾,3,5,11-tetraen-10-one 
• 1370698-60-4 C₂₆H₂₂F₂N₄O 
• 1042036-55-4 1-benzyl-4-phenyl-1H-pyridin-2-one 
• 1202927-35-2 N-benzyl-2-(2-oxo-4-phenylpyridn-1(2H)-yl)isonicotinamide 
• 1358778-32-1 ethyl (2R)-2-methyl-2-(methylsulfonyl)-4-(2-oxo-4-phenylpyridin-1(2H)-yl)butanoate 

Relevant academic research and scientific papers

Magnesiate-Utilized/Benzyne-Mediated Approach to Indenopyridones from 2-Pyridones: An Attempt to Synthesize the Indenopyridine Core of Haouamine

An efficient, short-staged synthesis of cis-fused indeno[2,1-b]- and indeno[1,2-c]pyridin-2-ones, starting from 2-pyridones, using magnesiates of type R3MgLi as nucleophilic and deprotonation agents, mediated by benzyne generated in situ, under optimized conditions, is described. Following the developed protocol, rare C4a-arylsubstituted indeno[2,1-b]pyridones, resembling the core of haouamine, were obtained. The protocol offering the one-pot synthesis directly from 2-pyridone is also described.

Facile Route to 2-Fluoropyridines via 2-Pyridyltrialkylammonium Salts Prepared from Pyridine N-Oxides and Application to 18F-Labeling

Among known precursors for 2-[18F]fluoropyridines, pyridyltrialkylammonium salts have shown excellent reactivity; however, their broader utility has been limited because synthetic methods for their preparation suffer from poor functional group

ORGANIC COMPOUNDS

The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.

8-Azabicyclo[3.2.1]octane derivatives

The present invention relates to a 8-azabicyclo[3.2.1]octane derivative of Formula I, wherein each of the substituents is given the definition as set forth in the specification and claims, or a pharmaceutically acceptable salt thereof or solvate thereof. The present invention also relates to a pharmaceutical composition comprising an 8-azabicyclo[3.2.1]octane derivative in admixture with one or more pharmaceutically acceptable auxiliaries and to the use of the 8-azabicyclo[3.2.1]octane derivative in therapy.

8-AZABICYCLO[3.2.1]OCTANE DERIVATIVES USEFUL AS MONOAMINE REUPTAKE INHIBITORS

The present invention relates to a 8-azabicyclo[3.2.1]octane derivative of Formula I, wherein R1 is H or C1-5alkyl; Y is O, S or O(CH2)m; m is 1 or 2; n is 0 or 1; Ar1 is phenylene or pyridylene, said phenylene and pyridylene being 1,3-linked with respect to O and when n is 1 with Y and when n is 0 with Ar2, said phenylene or pyridylene being optionally substituted with one or two substituents independently selected from halogen, C1-5alkyl, C1-5alkoxy, C3-6cycloalkyl, C2-5alkenyl, C2-5alkynyl, phenyl, CN and hydroxy, wherein said C1-5alkyl and C1-5alkoxy are optionally substituted with one to three halogens and wherein the oxygen of said hydroxy is optionally bonded to Ar2 to form a 5-membered ring; Ar2 is phenyl or a 5-6 membered heteroaryl, said phenyl or 5-6 membered heteroaryl being optionally substituted with one to three substituents independently selected from halogen, C1-5alkyl, C1-5alkoxy, CN, CONR2R3, CO2R4, NHCOR5 and hydroxy, wherein said C1-5alkyl and C1-5alkoxy are optionally substituted with one to three halogens and wherein the oxygen of said hydroxy is optionally bonded to Ar1 to form a 5-membered ring; R2-R4 are independently H or C1-5alkyl and R5 is C1-5alkyl, or a pharmaceutically acceptable salt or solvate thereof. The present invention also relates to a pharmaceutical composition comprising a 8- azabicyclo[3.2.1]octane derivative according to the present invention in admixture with one or more pharmaceutically acceptable auxiliaries and to the use of a 8- azabicyclo[3.2.1]octane derivative according to the present invention in therapy.

Synthesis and SAR of highly potent and selective dopamine D 3-receptor antagonists: Variations on the 1H-pyrimidin-2-one theme

In our efforts to further pursue one of the most selective dopamine D 3-receptor antagonists reported to date, we now describe the synthesis and SAR of novel and highly selective dopamine D3 antagonists based on a 1H-pyridin-2-one or

2-Pyridones from cyanoacetamides and enecarbonyl compounds: Application to the synthesis of nothapodytine B

The condensation of an enone or enal with cyanoacetamide derivatives and t-BuOK furnishes either 3-cyano-2-pyridones or 3-unsubstituted-2-pyridones, depending on whether the reaction is carried out in the presence or in the absence of O2. In the first case, in situ oxidation of Michael-type intermediates takes place; in the second case, the products result from "decyanidative aromatization" of such intermediates. A one-step synthesis of 3-alkyl-2-pyridones has been devised on the basis of decyanative union of an enone/enal and a 2-alkylcyanoacetamide. The new reaction forms the centerpiece of an unusually concise synthesis of nothapodytine B (mappicine ketone).

Convenient synthesis and transformation of 2,6-dichloro-4-iodopyridine

(Matrix Presented) We describe a convenient scalable synthesis of 2,6-dichloro-4-iodopyridine and demonstrate its utility by stepwise elaboration to a number of 2,4,6-trisubstituted pyridines.

2-Oxo-1,2-(dihydropyridyl)-2H-1-benzopyrans

The present invention is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof: STR1 wherein Y, R2, R3, R4, R5, R6, R7 , a and b are as defined in the Specifica

PHOTOCHEMISTRY OF PYRIDINE N-OXIDES. TRAPPING OF AN INTERMEDIATE WITH AMINES

The photochemistry of pyridine N-oxide (1a) and the corresponding 4-benzyl (1b), 4-phenyl (1c), and 2,6-dimethyl (1d) derivatives has been investigated or reinvestigated.Substrates 1a and 1b yield a small amount of the corresponding 2-acylpyrroles (5a,b) as the only isolable product, 1d yields 5d in moderate yield and 1c yields 5c in aprotic and the 2-pyridone 7c in protic solvents.In the presence of diethylamine isomeric 5-diethylaminopentadienenitriles (3,4) are obtained in moderate yield along with deoxygenated pyridines (6).Under this condition no 5 is formed, but the yield of 7 is unchanged.These reactions are most economically accunted for by admitting that nitrene 11 is formed as an intermediate and undergoes rearrangement to pyrroles 5 or polymerization to tars, or it can be trapped by amines (proton abstraction followed by nucleophilic substitution) to yield products 3 and 4.The lactams 7 arise directly from the N-oxide singlet excited state, which is also involved in the deoxygenation by amines.