25298-25-3Relevant academic research and scientific papers
Ruthenium-NHC Catalyzed α-Alkylation of Methylene Ketones Provides Branched Products through Borrowing Hydrogen Strategy
Schlepphorst, Christoph,Maji, Biplab,Glorius, Frank
, p. 4184 - 4188 (2016/07/12)
The α-alkylation of a broad range of methylene ketones was achieved using a ruthenium(II)-NHC catalyst under borrowing hydrogen conditions. Primary alcohols served as alkylating agents and could be used in a one-to-one stoichiometry with respect to the ketone. The selectivity of the process for methyl over branched ketones enabled a one-pot double alkylation protocol utilizing two different alcohols with a single catalyst. Moreover, this methodology could be applied directly to the one-step synthesis of donepezil, the best-selling drug for the treatment of Alzheimer's disease.
Synthesis of benzyl substituted naphthalenes from benzylidene tetralones
Deck, Lorraine M.,Mgani, Quintino,Martinez, Andrea,Martinic, Alice,Whalen, Lisa J.,Vander Jagt, David L.,Royer, Robert E.
scheme or table, p. 373 - 376 (2012/01/31)
A convenient and efficient synthesis of novel highly substituted dimethoxybenzylnaphthalenes, which are precursors to several dihydroxynaphthoic acids, is described. The approach involves the use of aldol chemistry to provide a number of benzylidene tetra
