2532-74-3

Basic information

• Product Name: 2-(1-Methyl-1H-indol-3-yl)-ethanol
• Synonyms: 2-(1-Methyl-1H-indol-3-yl)-ethanol
• CAS NO: 2532-74-3
• Molecular Formula: C₁₁H₁₃NO
• Molecular Weight: 175.22702
• Mol File: 2532-74-3.mol
• Article Data: 25

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(1-Methyl-1H-indol-3-yl)-ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1-Methyl-1H-indol-3-yl)-ethanol(2532-74-3)
• EPA Substance Registry System: 2-(1-Methyl-1H-indol-3-yl)-ethanol(2532-74-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 2532-74-3(Hazardous Substances Data)

Usage

Chemical Structure

Beta-carboline

+ Natural Occurrence

Found in a variety of plant sources, including tobacco smoke.

+ Neurotoxin

Identified as a neurotoxin that can have harmful effects on the central nervous system.

+ Potential Role in Neurological Disorders

Studied for its potential role in the development of neurological disorders such as Parkinson's disease and Alzheimer's disease.

+ Potential Carcinogenic Properties

Investigated for its potential carcinogenic properties.

Health and Environmental Concerns

The presence and effects of harmane in the human body raise concerns about its impact on health and the environment.

Upstream product

• 95688-82-7 3-(2-acetoxyethyl)-1-methylindole 
• 526-55-6 2-(3-indole)-ethanol 
• 74-88-4 methyl iodide 
• 603-76-9 1-methylindole 
• 1912-48-7 2-(1-methyl-1H-indol-3-yl)acetic acid 
• 87-51-4 indole-3-acetic acid 
• 778-82-5 ethyl 3-indoleacetate 
• 13137-14-9 acetic acid 2-(1H-indol-3-yl)ethyl ester 
• 2058-74-4 1-methyl-1H-indole-2,3-dione 
• 500220-01-9 methyl (N-methyl-3-hydroxy-2-oxindol-3-yl)-acetate 
• 58665-00-2 (1-methyl-1H-indol-3-yl)acetic acid methyl ester 
• 56999-62-3 ethyl 2-(1-methyl-1H-indol-3-yl)acetate 
• 18372-22-0 2-(3-indolyl)oxoacetic acid methyl ester 
• 22980-09-2 indolyl-3-glyoxylyl chloride 

Relevant articles and documents

Direct synthesis of dihydrobenzo[a]carbazoles via palladium-catalyzed domino annulation of indoles

A straightforward one-step synthesis of annulated indoles via palladium-catalyzed, norbornene-mediated sequential intermolecular aryl ortho-alkylation/intramolecular indole C-H activation has been devised. This method provides an efficient route to a wide variety of substituted 6,11-dihydro-5H-benzo[a]carbazoles from readily accessible 3-bromoalkylindoles and iodoarenes.

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Exploration of a KI-catalyzed oxidation system for direct construction of bispyrrolidino[2,3-: B] indolines and the total synthesis of (+)-WIN 64821

A facile and environmentally benign KI(cat.)/NaBO3·4H2O oxidation system has been developed for the tandem oxidative aminocyclization/coupling of tryptamines, affording a series of 3a,3a′-bispyrrolidino[2,3-b]indolines with high efficiency (up to 94% yield). This reaction features an electrophilic "I+" mechanism, which is importantly quite different from and milder than the typical radical-involving process, and can be readily amplified for the total synthesis of (+)-WIN 64821.

Rapid One-Pot Access to Unique 3,4-Dihydrothiopyrano[3,4-b]indol-1(9H)-imines via Bi(OTf)3-Catalysed Tandem Friedel–Crafts Alkylation/Thia-Michael Addition

A highly efficient and atom economical one-pot annulation strategy for novel tetrahydrothiopyrano[3,4-b]indoles is presented. This protocol involves a Bi(OTf)3 catalyzed tandem Friedel–Crafts alkylation and intramolecular thia-Michael addition reactions to furnish target molecules in an efficient manner. The method works effectively on substrates with unprotected indoles and also it is successfully employed to make tetrahydrothiepino[3,4-b]indoles. The scaffolds synthesized are diverse and first of the kind. The reaction is practically simple with broad substrate scope and vast functional group compatibility.