253273-91-5

Upstream product

• 19315-93-6 6-hydroxy-1H-quinolin-2-one 
• 253273-90-4 3-[3-(bromomethyl)phenyl]-5-methyl-1,2,4-oxadiazole 
• 87944-75-0 5-Methyl-3-(m-tolyl)-1,2,4-oxadiazole 

Relevant academic research and scientific papers

N-aryl heterocycles via coupling reactions with arylboronic acids

Compounds having a partial 2-pyridone structure or 3-pyridazinones can be selectively N-arylated with phenylboronic acids according to the procedure described by Chan and Lam. This procedure leads to N5-arylated imidazo[4,5- c]pyridin-4-ones, precursors of potent factor Xa inhibitors. In addition, the synthesis of N-aryl substituted pyrrole- and indole-2-carboxylic acid esters is described. In the indole series this procedure offers a flexible entry in the synthesis of different 1,3-diaryl-2-carboxyindoles.