253345-86-7Relevant academic research and scientific papers
The stereoselective synthesis of cyclopropylphosphonate analogs of nucleotides
Hah, Jung Hwan,Gil, Jun Mo,Oh, Dong Young
, p. 8235 - 8238 (2007/10/03)
1-Alkenylphosphonic acid derivatives of purines have been proven to exhibit significant antiviral activity among these series of compounds. Here we disclose the stereoselective synthesis of the constrained analogs of 1-alkenylphosphonate derivatives of purines via intramolecular epoxide opening reaction of γ,δ-epoxyalkanephosphonates with subsequent Mitsunobu coupling reactions with purine bases.
