174832-87-2

Upstream product

• 18276-82-9 diethyl 2-(p-chlorophenyl)-2-oxo-ethylphosphonate 
• 106-95-6 allyl bromide 
• 623-03-0 4-Cyanochlorobenzene 
• 15916-48-0 diethyl but-3-en-1-ylphosphonate 

Downstream Products

• 1256943-69-7 C₁₅H₂₀ClO₅P 
• 253345-86-7 [2-(4-chloro-phenyl)-1-oxiranylmethyl-2-oxo-ethyl]-phosphonic acid diethyl ester 
• 35204-91-2 1-(4-chlorophenyl)pent-4-en-1-one 

Relevant academic research and scientific papers

The stereoselective synthesis of cyclopropylphosphonate analogs of nucleotides

1-Alkenylphosphonic acid derivatives of purines have been proven to exhibit significant antiviral activity among these series of compounds. Here we disclose the stereoselective synthesis of the constrained analogs of 1-alkenylphosphonate derivatives of purines via intramolecular epoxide opening reaction of γ,δ-epoxyalkanephosphonates with subsequent Mitsunobu coupling reactions with purine bases.

New synthetic route to 3-furylphosphonates

A method for the preparation of 3-furylphosphonates has been developed starting with the addition of homoallylic phosphonates to nitrile, followed by a sequence consisting of acidic hydrolysis, iodine-mediated cyclization and dehydroiodination by DBU.