253353-33-2Relevant academic research and scientific papers
Efficient synthesis of a novel 4-hydroxy-2,3-dioxocyclobut-1-enyl group containing amino acids
Shinada, Tetsuro,Hayashi, Ken-Ichi,Hayashi, Toshihiro,Yoshida, Yasutaka,Horikawa, Manabu,Shimamoto, Keiko,Shigeri, Yasushi,Yumoto, Noboru,Ohfune, Yasufumi
, p. 1663 - 1666 (2008/02/10)
matrix presented Syntheses of novel amino acids possessing a squaryl group, 1-3, in an optically active form are described. The syntheses of 1-3 were conducted by a concise route involving (1) an aldol addition of an enolate derived from Gly, L-Asp, or L-Glu to diisopropyl squarate (4) and (2) an efficient decarboxylation of the aldol adducts based on the electron-withdrawing property of the squaryl group. Introducing N-protected group to 2 and 3 and peptide formation reactions are also described.
