25342-53-4Relevant academic research and scientific papers
A convenient synthesis of hindered amines and α-trifluoromethylamines from ketones
Barney, Charlotte L.,Huber, Edward V.,McCarthy, James R.
, p. 5547 - 5550 (1990)
Ketones and α-trifluoromethylketones were converted to primary, secondary, and tertiary amines in good to excellent yields by a reductive amination procedure utilizing TiCl4/NaCNBH3. The method provides the first direct route to α-trifluoromethylamines from ketones, and access to hindered amines from ketones which are unobtainable by Borch reductive amination.
