A convenient synthesis of hindered amines and α-trifluoromethylamines from ketones

Article abstract of DOI:10.1016/S0040-4039(00)97893-6

Ketones and α-trifluoromethylketones were converted to primary, secondary, and tertiary amines in good to excellent yields by a reductive amination procedure utilizing TiCl₄/NaCNBH₃. The method provides the first direct route to α-trifluoromethylamines from ketones, and access to hindered amines from ketones which are unobtainable by Borch reductive amination.