
Tetrahedron Letters p. 5547 - 5550 (1990)
Update date:2022-08-04
Topics:
Barney, Charlotte L.
Huber, Edward V.
McCarthy, James R.
Ketones and α-trifluoromethylketones were converted to primary, secondary, and tertiary amines in good to excellent yields by a reductive amination procedure utilizing TiCl4/NaCNBH3. The method provides the first direct route to α-trifluoromethylamines from ketones, and access to hindered amines from ketones which are unobtainable by Borch reductive amination.
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