25343-67-3

Upstream product

• 56-23-5 tetrachloromethane 
• 98-82-8 Isopropylbenzene 
• 505-14-6 thiocyanogen 
• 540-72-7 sodium thiocyanide 
• 98-83-9 isopropenylbenzene 
• 60245-52-5 (2-iodo-1-isothiocyanato-1-methyl-ethyl)-benzene 
• 5961-98-8 thiocyanatochloride 
• 934-53-2 cumenyl chloride 
• 1147550-11-5 ammonium thiocyanate 
• 617-94-7 1-methyl-1-phenylethyl alcohol 
• 585-32-0 2-phenyl-2-propylamine 
• 75-15-0 carbon disulfide 
• 7664-93-9 sulfuric acid 
• 2290-65-5 trimethylsilyl isothiocyanate 

Downstream Products

• 32767-63-8 N,N'-bis-(1-methyl-1-phenyl-ethyl)-thiourea 
• 24053-66-5 N,N-dimethyl-N'-(1-methyl-1-phenyl-ethyl)-thiourea 
• 66896-49-9 N-methylcumylamine 
• 1401349-50-5 N-(2-phenylpropan-2-yl)-5-(3-(pyrimidin-2-yl)-1-tosyl-1H-indol-5-yl)-1,3,4-oxadiazol-2-amine 
• 95880-21-0 N-(2-phenylpropan-2-yl)hydrazinecarbothioamide 
• 1401349-46-9 5-(3-(6-cyclopropylpyrazin-2-yl)-1-tosyl-1H-indol-5-yl)-N-(2-phenylpropan-2-yl)-1,3,4-oxadiazol-2-amine 
• 1401349-45-8 N-(2-phenylpropan-2-yl)-5-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1H-indol-5-yl)-1,3,4-oxadiazol-2-amine 
• 1401349-44-7 5-(3-iodo-1-tosyl-1H-indol-5-yl)-N-(2-phenylpropan-2-yl)-1,3,4-oxadiazol-2-amine 
• 24053-81-4 N¹,N¹-Diisopropyl-N²-(α,α-dimethyl-benzyl)-formamidin 
• 24053-80-3 N¹,N¹-Dimethyl-N²-(α,α-dimethyl-benzyl)-formamidin 
• 102660-50-4 N-Methyl-N-<2-phenyl-propyl-(2)>-N'-naphthyl-(1)-harnstoff 
• 24053-67-6 N¹,N¹-Diisopropyl-N²-(α,α-dimethyl-benzyl)-thioharnstoff 
• 109473-49-6 morpholine-4-carbothioic acid 1-methyl-1-phenyl-ethylamide 

Relevant academic research and scientific papers

Reaction of Thiocarbonyl Fluoride Generated from Difluorocarbene with Amines

The reaction of thiocarbonyl fluoride, generated from difluorocarbene, with various amines under mild conditions is described. Secondary amines, primary amines, and o-phenylenediamines are converted to thiocarbamoyl fluorides, isothiocyanates, and difluoromethylthiolated heterocycles, respectively. Thiocarbamoyl fluorides were further transformed into trifluoromethylated amines by using a one-pot process. Thiocarbonyl fluoride is generated in situ and is rapidly fully converted in one pot under mild conditions; therefore, no special safety precautions are needed.

AZOLE COMPOUNDS AS PIM INHIBITORS

The invention relates to bicyclic compounds of formulas I and Ia, and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further em

Phosphine-free conversion of alcohols into alkyl thiocyanates using trichloroisocyanuric acid/NH4SCN

A convenient and efficient phosphine-free procedure for the one-pot conversion of primary, secondary and tertiary alcohols into the corresponding alkyl thiocyanates or alkyl isothiocyanates is described using trichloroisocyanuric acid/NH4SCN.

Isothiocyanates from tosyl chloride mediated decomposition of in situ generated dithiocarbamic acid salts

(Chemical Equation Presented) A facile and general protocol for the preparation of isothiocyanates from alkyl and aryl amines is reported. This method relies on a tosyl chloride mediated decomposition of a dithiocarbamate salt that is generated in situ by treatment of an amine with carbon disulfide and triethylamine. Utilizing this protocol, we have prepared 19-alkyl- and arylisothiocyanates in moderate to excellent yield.

Oxalic acid-catalyzed reaction of alcohols with NaSCN: The effects of additives NaI and i2

Oxalic acid-mediated conversion of alcohols to thiocyante and/or isothiocyanate is described. Aliphatic tertiary alcohols give isothiocyanate by the reaction with NaSCN in the presence of I2, whereas they give thiocyanate without it. Copyright

Bromothiocyanation of Alkenes

Treatment of alkenes with "thicyanogen bromide" prepared from equimolar amounts of bromine and thallium (1) thiocyanate in wet chloroform, gives moderate to high yields of vic-bromothiocyanates.The addition proceeds by an ionic mechanism involving nucleophilic attack of bromide ion on anS-cyanothiiranium cation.Unlike vic-iodothiocyanates, the vic-bromothiocyanates are not readily isomerized to the corresponding vic-halogenoisothiocyanates.