25356-78-9

Upstream product

• 514-10-3 (?)-abietic acid 
• 30906-06-0 Methyl-12-acetoxydehydroabietat 
• 55623-34-2 (1R,4aR)-7-Isopropyl-1,4a-dimethyl-6-oxo-1,2,3,4,4a,4b,5,6,10,10a-decahydro-phenanthrene-1-carboxylic acid methyl ester 
• 64-19-7 acetic acid 
• 127-25-3 abietic acid methyl ester 
• 3484-53-5 (1R,4aR,6S)-6-Hydroxy-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,4b,5,6,10,10a-decahydro-phenanthrene-1-carboxylic acid methyl ester 

Downstream Products

• 116032-84-9 lambertic acid 

Relevant academic research and scientific papers

Synthesis of 4- epi-Parviflorons A, C, and E: Structure-Activity Relationship Study of Antiproliferative Abietane Derivatives

The first syntheses of 4-epi-parviflorons A, C, and E (4-epi-1-3) were achieved in 12-13 steps from commercially available (-)-abietic acid (5). All synthesized compounds, including intermediates and derivatives, were evaluated for antiproliferative activity against five human tumor cell lines. A structure-activity relationship study revealed no significant difference between Pf E and 4-epi-Pf E, the importance of two oxygen functional groups at C-11 and C-12 for antiproliferative activity, as well as a combination of carbomethoxy at C-4 and a benzoyl ester with electron-drawing group at C-12 or hydroxymethyl at C-4 and an appropriate oxidation state of ring-B/C for triple-negative breast cancer cell selectivity.