25366-23-8

Basic information

• Product Name: THIAZAFLURON
• Synonyms: 2-(n,n’-dimethylureido)-5-trifluoromethyl-1,3,4-thiadiazole;4-thiadiazole,2-(n,n’-dimethylureido)-5-trifluoromethyl-3;dmttu;erbotan;gs29296;n,n’-dimethyl-n-(5-trifluoromethyl-1,3,4-thiadiazol-2-yl)urea;THIAZAFLURON;1,3-DIMETHYL-1-(5-TRIFLUOROMETHYL-1,3,4-THIADIAZOL-2-YL)-UREA
• CAS NO: 25366-23-8
• Molecular Formula: C₆H₇F₃N₄OS
• Molecular Weight: 240.21
• EINECS: 246-901-4
• Product Categories: Alpha sort;Herbicides;Pesticides&Metabolites;Q-ZAlphabetic;TF - TOPesticides&Metabolites;Urea structure
• Mol File: 25366-23-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 136.5°C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.507g/cm³
• Refractive Index: 1.519
• PKA: 13.14±0.46(Predicted)
• Water Solubility: 2.096g/L(20 oC)
• BRN: 806900
• CAS DataBase Reference: THIAZAFLURON(CAS DataBase Reference)
• NIST Chemistry Reference: THIAZAFLURON(25366-23-8)
• EPA Substance Registry System: THIAZAFLURON(25366-23-8)

Safety Data

• Hazard Codes: Xn,N
• Statements: 22-50/53
• Safety Statements: 60-61
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: XI3760000
• Hazardous Substances Data: 25366-23-8(Hazardous Substances Data)

Usage

General Description

Thiazfluron is a chemical compound known for its herbicidal properties, used to control weeds in various crops. It belongs to the class of phenylpyrazole herbicides and acts as a selective inhibitor of the protoporphyrinogen oxidase (PPO) enzyme, essential for chlorophyll biosynthesis in plants. Thiazfluron has a broad spectrum of activity against both grassy and broad-leaved weeds, making it an effective tool for weed management in agricultural fields. It is often formulated as a water dispersible granule or suspension concentrate for application as a foliar spray, providing long-lasting control of target weeds while being safe for use on crop plants when applied at recommended rates. Thiazfluron is considered to have a favorable environmental profile due to its low persistence and low toxicity to non-target organisms.

InChI:InChI=1/C6H7F3N4OS/c1-10-4(14)13(2)5-12-11-3(15-5)6(7,8)9/h1-2H3,(H,10,14)

Upstream product

• 6452-47-7 methylcarbamoyl chloride 
• 25366-22-7 N-methyl-5-(trifluoromethyl)-1,3,4-thiadiazol-2-amine 
• 74-89-5 methylamine 

Relevant articles and documents

Preparation method of thiazafluron original medicine

The invention relates to a preparation method of a thiazafluron original medicine. The method comprises the following steps: dropwise adding an N-methylaminoformyl chloride solution into a 2-methyl ammonia-(5-trifluoromethyl)-1,3,4-thiadiazole solution; then introducing nitrogen after dropwise adding organic alkali; then after heating and cooling reactions, adding water to react; and filtering anddrying the solution to obtain a white solid thiazafluron. According to the preparation method, flammable and combustible methyl isocyanate which is unlikely to transport is not used, and a product which is high in yield and purity can be obtained without recrystallization.

Thiadiazole compounds and methods of using said compounds in agriculture

Novel thiadiazole compounds are disclosed which contain in the 5 position, C-linked moieties which are either acyclic hydrocarbon radicals or halogenated acyclic hydrocarbon radicals (in which case each halogen is independently selected from F, Cl and Br). These novel compounds also contain an exocyclic nitrogen in the 2 position, and some of them contain the exocyclic substituent: STR1 wherein R3 is a lower acyclic hydrocarbon radical and R4 is either H or a lower acyclic hydrocarbon radical. Synthesis of these compounds is disclosed, including synthesis of those which exhibit isomerism and/or tautomerism. Various of these compounds have various agricultural utilities (e.g. as herbicides, insecticides, acaricides and fungicides), each of them having at least one such biological utility. Methods of using these compounds in phytotoxic fungicidal, acaricidal and insecticidal applications are disclosed.

5-Substituted thiadiazole ureas

New thiadiazole ureas are provided for the control of plant growth, especially of undesirable weeds and grasses. Particularly effective are compounds which contain an organic substituent in the 5-position of the thiadiazole portion.