6452-47-7 Usage
Description
Methylcarbamoyl Chloride is used as a reagent in the synthesis of acylprolinamides as a new class of peptide deformylase inhibitors with in vivo antibacterial activity. Methylcarbamoyl Chloride is also used as a reagent in the synthesis of carbamate derivatives as potential dual-binding site acetylcholinesterase inhibitors. The decomposition tail gas hydrogen chloride of Methylaminoformyl chloride is also useful during the cartap synthesis.
Uses
Different sources of media describe the Uses of 6452-47-7 differently. You can refer to the following data:
1. Methylaminoformyl chloride can be widely used as an intermediate of carbamate insecticides such as Zhongdingwei, carbofuran, isoprocarb, methomyl, chlorhexidine and carbaryl.
Methylaminoformyl chloride is also used as a reagent in the synthesis of carbamate derivatives as potential dual-binding site acetylcholinesterase inhibitors. The decomposition tail gas hydrogen chloride of Methylaminoformyl chloride is also useful during the cartap synthesis.
2. Methylcarbamoyl Chloride is used as a reagent in the synthesis of acylprolinamides as a new class of peptide deformylase inhibitors with in vivo antibacterial activity. Methylcarbamoyl Chloride is also used as a reagent in the synthesis of carbamate derivatives as potential dual-binding site acetylcholinesterase inhibitors.
Preparation
Methylaminoformyl chloride is prepared by reacting methylamine with phosgene. Reaction equation: CH3NH2+COCl2→CH3NHCOCl. A 40% aqueous solution of methylamine is vaporized, and after drying, it is combined with phosgene at a ratio of 1:1.3 (methanol), methylamine at 4 m3/h, and phosgene at a rate of 8.6 m3/h (content 60%-70%). Preheating into the preheater, the preheating temperature of methylamine is controlled at 220-260°C, and the phosgene is controlled at 200-240°C. The preheated two gases enter the test tube and are synthesized at 280-300°C to obtain gaseous methaqualyl chloride. Then, carbon tetrachloride (or chlorobenzene solution) is circulated and absorbed at 0-20°C to obtain a solution of about 10% of carbamoyl chloride (or chlorobenzene), or cooled to a liquid product after 35-40°C or lower[2,3].
Synthesis Reference(s)
Journal of the American Chemical Society, 72, p. 1888, 1950 DOI: 10.1021/ja01161a009
Check Digit Verification of cas no
The CAS Registry Mumber 6452-47-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,4,5 and 2 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 6452-47:
(6*6)+(5*4)+(4*5)+(3*2)+(2*4)+(1*7)=97
97 % 10 = 7
So 6452-47-7 is a valid CAS Registry Number.
InChI:InChI=1/C2H4ClNO/c1-4-2(3)5/h1H3,(H,4,5)
6452-47-7Relevant articles and documents
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Buder,Schmidt
, p. 1429,1430, 1434 (1973)
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Preparation of carbamoyl halides
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, (2008/06/13)
Compounds of formula I, RNHCOCl (I), where R is an optionally substituted alkyl or aryl group, are obtained by chlorinating a compound of formula II, RNHCHO (II), in the absence of a solvent.
Preparation of alkyl isocyanates
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, (2008/06/13)
A novel process for the preparation of alkyl isocyanates comprising reacting COX2 and an alkyl amine hydrohalide of the formula wherein R is alkyl of 1 to 3 carbon atoms and X is a halogen either under pressure in an inert organic solvent or under atmospheric pressure in a high boiling organic solvent to form the corresponding alkyl carbamoyl halide, reacting the latter in an organic solvent with an urea of the formula STR1 wherein X' is selected from the group consisting of oxygen and sulfur, R1 and R3 are individually selected from the group consisting of alkyl of 1 to 7 carbon atoms, cycloalkyl of 4 to 6 carbon atoms and phenyl and R2 and R4 are individually selected from the group consisting of hydrogen, alkyl of 1 to 7 carbon atoms, cycyloalkyl of 4 to 6 carbon atoms and phenyl to obtain the corresponding alkyl isocyanate.
