25370-94-9Relevant academic research and scientific papers
A "dual-function" photocage releasing nitric oxide and an anthrylmethyl cation with a single wavelength light
Vittorino, Elisa,Cicciarella, Enzo,Sortino, Salvatore
experimental part, p. 6802 - 6806 (2010/01/21)
A dual function photocage able to associate the generation of an anthrylmethyl carbocation to the release of NO, under the control of a low energy single wavelength light, was reported. The O-alkylation of cupferron (CP) was accomplished by designing and
O-Alkylation of Cupferron: Aiming at the Design and Synthesis of Controlled Nitric Oxide Releasing Agents
Hou, Yongchun,Xie, Wenhua,Janczuk, Adam J.,Wang, Peng George
, p. 4333 - 4337 (2007/10/03)
O-Alkylation of N-nitroso-N-phenylhydroxylamine ammonium salt (cupferron) was studied for the synthesis of novel nitric oxide (NO) releasing agents. The alkylation occurred regioselectively at the terminal oxygen, leading to a single product N-(alkyloxy)-N′-phenyldiimide N′-oxide as indicated by NMR and X-ray analysis. The O-alkyl derivatives exhibited significantly improved stability compared to their parent compound, cupferron. It was demonstrated that the cupferron O-alkyl derivatives could function as photoreleasing NO donor compounds. N-(N″-acetylphenylalanylmethylenyloxy)-N′-phenyldiimide N′-oxide), which linked the cupferron portion with an amino acid via an acetal moiety, was synthesized as an model NO prodrug where controlled NO release would occur either by increasing pH or by a protease-catalyzed hydrolysis.
SYNTHESIS OF N'-METHOXYDIAZENE N-OXIDES FROM METHOXYAMINE AND NITROSO COMPOUNDS
Luk'yanov, O. A.,Smirnov, G. A.,Vasil'ev, A. M.
, p. 1966 - 1968 (2007/10/02)
The reaction of methoxyamine with nitroso compounds in the presence of oxidizing agents is rather general in nature and may serve as a convenient method for the synthesis of aliphatic, aromatic, and heterocyclic N'-alkoxydiazene N-oxides.
